{"id":"W4315796052","doi":"10.1016/j.celrep.2023.112014","title":"Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Centre for Phenogenomics","funders":"NHLBI Division of Intramural Research; National Institute of Allergy and Infectious Diseases; Defense Health Agency; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation; Chongqing Medical University; Guangzhou Municipal Science and Technology Bureau; U.S. Army Medical Research and Development Command; GHR Foundation; KU Leuven; Chongqing Science and Technology Commission; Bill and Melinda Gates Foundation; U.S. Army; U.S. Department of Defense","keywords":"Neutralization; Avidity; Bivalent (engine); Spike Protein; Epitope; Chemistry; Antibody; Virology; Binding site; Biophysics; Molecular biology; Biology; Coronavirus disease 2019 (COVID-19); Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001318953,0.0003062848,0.000508882,0.0001690038,0.0001510048,0.00006748064,0.0001613821,0.0002125831,0.0000255725],"category_scores_gemma":[0.001933956,0.0002661553,0.0002616771,0.0008075998,0.000181499,0.00008180497,0.0002375423,0.0003640927,0.000297191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004984693,"about_ca_system_score_gemma":0.0007700165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055127,"about_ca_topic_score_gemma":0.0001159857,"domain_scores_codex":[0.9960594,0.0001029537,0.001230738,0.001100249,0.0007902877,0.0007163807],"domain_scores_gemma":[0.9978194,0.0002120825,0.000367951,0.001217058,0.0002069844,0.0001764842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000917205,0.000550574,0.3349038,0.0004573788,0.0001364482,0.01135878,0.0005962395,0.000014271,0.6200243,0.00000265082,0.02168058,0.009357718],"study_design_scores_gemma":[0.0023055,0.0002592514,0.0465566,0.0003034041,0.0001245243,0.0001312361,0.0006420597,0.0007419328,0.7041793,0.0001634769,0.244127,0.0004656618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889233,0.0003993436,0.00001976027,0.0007240296,0.001094525,0.00106366,0.0001171104,0.0004300844,0.007228255],"genre_scores_gemma":[0.9959014,0.00007112116,0.0001101921,0.002782755,0.0003943238,0.00007242682,0.0001981211,0.00003984214,0.0004298144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2883472,"threshold_uncertainty_score":0.9999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04654141364211973,"score_gpt":0.3325475313784112,"score_spread":0.2860061177362915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}