{"id":"W4315796052","doi":"10.1016/j.celrep.2023.112014","title":"Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Centre for Phenogenomics","funders":"NHLBI Division of Intramural Research; National Institute of Allergy and Infectious Diseases; Defense Health Agency; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation; Chongqing Medical University; Guangzhou Municipal Science and Technology Bureau; U.S. Army Medical Research and Development Command; GHR Foundation; KU Leuven; Chongqing Science and Technology Commission; Bill and Melinda Gates Foundation; U.S. Army; U.S. Department of Defense","keywords":"Neutralization; Avidity; Bivalent (engine); Spike Protein; Epitope; Chemistry; Antibody; Virology; Binding site; Biophysics; Molecular biology; Biology; Coronavirus disease 2019 (COVID-19); Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116688,0.0004089011,0.0002690284,0.0002714635,0.0002604746,0.0004357712,0.0003026068,0.0003023908,0.002496139],"category_scores_gemma":[0.0005147752,0.0000729692,0.0002895335,0.0003002703,0.00024167,0.0002396996,0.0004786181,0.0004659211,0.0003310182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046313,"about_ca_system_score_gemma":0.000263339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001891206,"about_ca_topic_score_gemma":0.002745281,"domain_scores_codex":[0.999443,0.0001452124,0.0000276877,0.0001023229,0.0001451529,0.0001366715],"domain_scores_gemma":[0.999622,0.00007326205,0.00003434683,0.0000724649,0.0001303973,0.00006761715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002630427,0.002810921,0.02690395,0.0002418066,0.0002237109,0.00029128,0.0006424954,0.00114036,0.8975646,0.0005286293,0.003284092,0.06373764],"study_design_scores_gemma":[0.0006447453,0.03394566,0.1153044,0.0000364992,0.0004553937,0.001690507,0.0009891588,0.002655827,0.8190626,0.0003313283,0.02484348,0.00004040544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965064,0.0004744703,0.0007266883,0.00008879946,0.00000855655,0.00004659955,0.0002718396,0.00001699782,0.001859542],"genre_scores_gemma":[0.9938276,0.0006617291,0.001026845,0.0001658579,0.00001369415,0.00004424633,0.001626368,0.00001951831,0.002614022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496139,"threshold_uncertainty_score":0.008350492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04654141364211973,"score_gpt":0.3325475313784112,"score_spread":0.2860061177362915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}