{"id":"W4315864682","doi":"10.1016/j.jpba.2023.115252","title":"Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples","year":2023,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Chemistry; Nat; Taurine; Chromatography; Repeatability; Detection limit; High-performance liquid chromatography; Quantitative analysis (chemistry); Mass spectrometry; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005863506,0.001920371,0.001118072,0.001938437,0.001315539,0.001135338,0.001354306,0.002467813,0.0009966025],"category_scores_gemma":[0.005804453,0.0007543647,0.001002625,0.0008911165,0.001907995,0.0008456144,0.001445342,0.001649537,0.001345304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009007929,"about_ca_system_score_gemma":0.00259589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00183308,"about_ca_topic_score_gemma":0.003104295,"domain_scores_codex":[0.9934304,0.001323667,0.0005675014,0.001541778,0.002852345,0.0002843758],"domain_scores_gemma":[0.9972094,0.0007903133,0.0003917267,0.0003327713,0.001136446,0.0001394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002177455,0.0001052165,0.001093911,0.000264442,0.00007449254,0.0001501713,0.000119666,0.0004328466,0.9890537,0.0002823308,0.0001521353,0.008053224],"study_design_scores_gemma":[0.00005350775,0.000709231,0.004813829,0.00008119525,0.0001215308,0.001197062,0.00007172758,0.007729702,0.9798428,0.0003000833,0.005004465,0.00007486816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3953909,0.009944202,0.5808163,0.0007805326,0.0006868569,0.002473486,0.002595719,0.003404571,0.003907471],"genre_scores_gemma":[0.4507068,0.004865912,0.5303079,0.001237768,0.0002195527,0.00386829,0.00310003,0.0004703198,0.005223551],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005863506,"threshold_uncertainty_score":0.03100955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05717231473661113,"score_gpt":0.4028098812228528,"score_spread":0.3456375664862417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}