{"id":"W4315926803","doi":"10.1159/000529099","title":"Advances and Clinical Trials Update in the Treatment of Diffuse Intrinsic Pontine Gliomas","year":2023,"lang":"en","type":"review","venue":"Pediatric Neurosurgery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Medicine; Personalized medicine; Clinical trial; Glioma; Biopsy; Precision medicine; Oncology; Modalities; Internal medicine; Pathology; Bioinformatics; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002557786,0.0005500519,0.005153361,0.0009271892,0.00004350382,0.00003565134,0.0001372315,0.0002485705,0.00001370827],"category_scores_gemma":[0.002190018,0.0002817383,0.001572214,0.0015138,0.00008519621,0.00004924816,0.00005231929,0.000263618,0.00004742242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005267157,"about_ca_system_score_gemma":0.0002163982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002453572,"about_ca_topic_score_gemma":0.00001154457,"domain_scores_codex":[0.9939873,0.001618854,0.002951732,0.0006779454,0.000391675,0.0003724645],"domain_scores_gemma":[0.9840555,0.01374943,0.001320303,0.0006657346,0.0000419002,0.0001671613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007754006,0.003288487,0.03375285,0.005600409,0.0002081567,0.00227229,0.00002133373,3.701874e-8,4.827824e-8,0.00001058181,0.001278048,0.9534902],"study_design_scores_gemma":[0.00305533,0.001028365,0.007454353,0.001021221,0.009310218,0.0001967396,0.000008524801,7.305016e-7,6.845466e-7,0.00002410019,0.9776561,0.0002436467],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03159511,0.964844,1.580856e-7,0.0002319887,0.0009720804,0.002140247,0.0001423039,0.00004654428,0.00002749115],"genre_scores_gemma":[0.0005924235,0.9972076,0.00001105184,0.00006040505,0.001441533,0.0004466137,0.0001353573,0.00007200958,0.00003298183],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.976378,"threshold_uncertainty_score":0.9999635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1857186167456512,"score_gpt":0.4479698325187169,"score_spread":0.2622512157730657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}