{"id":"W4315928236","doi":"10.1016/j.chom.2022.11.014","title":"Oncomicrobial vaccines: The potential for a Fusobacterium nucleatum vaccine to improve colorectal cancer outcomes","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Simon Fraser University; Vancouver Coastal Health","funders":"Cancer Research UK","keywords":"Fusobacterium nucleatum; Colorectal cancer; Biology; Virology; Fusobacterium; Cancer; Immunology; Bacteria; Genetics; Bacteroides","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982487,0.0002976184,0.0002993483,0.00007131995,0.0002892901,0.00007157122,0.0004345068,0.000209613,0.00007541464],"category_scores_gemma":[0.00002755689,0.0002259788,0.0002470697,0.0001932961,0.00002666003,0.000004972712,0.000342789,0.0001426716,0.0001669458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006682196,"about_ca_system_score_gemma":0.00022312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002031647,"about_ca_topic_score_gemma":0.0005029173,"domain_scores_codex":[0.9983342,0.00004056154,0.0003215612,0.0005686079,0.0000613864,0.0006736934],"domain_scores_gemma":[0.9991918,0.00002248973,0.0001134155,0.0003913902,0.000137784,0.0001431833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002960876,0.00005652085,0.0007516516,0.00006048032,0.00004778595,0.000002159861,0.0001489495,0.0000140899,0.8489712,0.000003106381,0.1493222,0.0003257233],"study_design_scores_gemma":[0.001959394,0.0004378743,0.03607463,0.00001427939,0.0000625236,0.00001107686,0.0001799947,0.00002005212,0.7385255,0.000005500219,0.2223542,0.0003550374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912442,0.0002042754,0.0001433735,0.004520195,0.00197914,0.001148104,0.0006166107,0.00005407476,0.0000900516],"genre_scores_gemma":[0.9864058,0.0002419869,0.0002931417,0.003626148,0.0009368052,0.0001771268,0.0004316546,0.00009486864,0.007792401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1104458,"threshold_uncertainty_score":0.9215149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005464215631737192,"score_gpt":0.2607527330322877,"score_spread":0.2552885174005505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}