{"id":"W4315928781","doi":"10.4049/jimmunol.2200465","title":"Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Arthritis Society; University of Toronto; York University","funders":"Canadian Institutes of Health Research; Arthritis Society; Government of Canada","keywords":"Inflammasome; Gout; Proinflammatory cytokine; NALP3; Knockout mouse; Secretion; Inflammation; Arthritis; Regulator; Caspase 1; Pathogenesis; Cytokine; Immunology; Medicine; Cancer research; Chemistry; Receptor; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004180082,0.0006352043,0.0006328666,0.000283425,0.000286725,0.0009628646,0.0004695737,0.0009602212,0.003646916],"category_scores_gemma":[0.0003588093,0.0001324278,0.0003779291,0.0001823911,0.0005888821,0.0007360349,0.0003245961,0.001521714,0.001046007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793475,"about_ca_system_score_gemma":0.0002945168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001949666,"about_ca_topic_score_gemma":0.0002819198,"domain_scores_codex":[0.9997008,0.00004279042,0.00003028629,0.00004905356,0.0001001158,0.00007699279],"domain_scores_gemma":[0.9997451,0.00004656842,0.0000820529,0.00002211419,0.00004724595,0.00005702853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001194407,0.0001073301,0.0007852366,0.0009419182,0.00004969654,0.0002929191,0.00004750328,0.0001911613,0.9596606,0.002300636,0.002506354,0.03192224],"study_design_scores_gemma":[0.0002268257,0.00187206,0.008121594,0.0002787483,0.0001895227,0.002786603,0.0001706479,0.001079264,0.9239323,0.003055375,0.05824464,0.00004247382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7370368,0.2067997,0.01188374,0.02378253,0.002611528,0.0001189731,0.001546193,0.0007825415,0.01543812],"genre_scores_gemma":[0.9560592,0.03204336,0.003143435,0.002519678,0.000504469,0.00003368858,0.0003778634,0.00007123416,0.005247174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003646916,"threshold_uncertainty_score":0.01220012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007418846080136617,"score_gpt":0.2253979783155462,"score_spread":0.2179791322354096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}