{"id":"W4316077668","doi":"10.14309/01.ajg.0000859600.82952.ab","title":"S740 Efficacy and Safety of Upadacitinib Maintenance Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Final Results From the Phase 3 U-ACHIEVE Maintenance Study","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Maintenance therapy; Discontinuation; Ulcerative colitis; Adverse effect; Internal medicine; Population; Clinical endpoint; Intention-to-treat analysis; Phases of clinical research; Gastroenterology; Clinical trial; Maintenance dose; Placebo; Surgery; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00151401,0.0004846231,0.001449958,0.0002220614,0.0002822931,0.0007403409,0.000422564,0.0006128738,0.002591329],"category_scores_gemma":[0.0009304571,0.0002145645,0.001086268,0.0003867949,0.000351539,0.0004261372,0.0002425911,0.001388386,0.0004834749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005626142,"about_ca_system_score_gemma":0.0009556568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006528442,"about_ca_topic_score_gemma":0.002191268,"domain_scores_codex":[0.9995521,0.0002006267,0.00003504543,0.00004741647,0.00008969534,0.00007507833],"domain_scores_gemma":[0.9994067,0.0001154133,0.0001767601,0.00004077905,0.00007549969,0.0001847341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6154014,0.01140586,0.02155578,0.00213585,0.004426364,0.0003946628,0.0002177621,0.001881938,0.03019059,0.0003559916,0.01464425,0.2973895],"study_design_scores_gemma":[0.4196928,0.4110417,0.13067,0.0003860839,0.005120945,0.001331393,0.0001187202,0.003012188,0.0127791,0.0004110904,0.01532327,0.0001128137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836669,0.009382553,0.0003827375,0.0005991497,0.0001052292,0.0008200346,0.001858691,0.00009671297,0.003088031],"genre_scores_gemma":[0.9925728,0.002129941,0.0007093268,0.0006006571,0.0001293782,0.000419579,0.002468857,0.00001602244,0.0009534064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002591329,"threshold_uncertainty_score":0.0086689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825038526053324,"score_gpt":0.2829838591746983,"score_spread":0.264733473914165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}