{"id":"W4316077747","doi":"10.14309/01.ajg.0000859572.34492.e6","title":"S733 Impact of Inflammatory Burden on Efficacy of Upadacitinib Maintenance Therapy in Ulcerative Colitis: Results From the Phase 3 U-ACHIEVE Study","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Maintenance therapy; Clinical endpoint; Pancolitis; Ulcerative colitis; Internal medicine; Placebo; Population; Clinical trial; Phases of clinical research; Surrogate endpoint; Post-hoc analysis; Post hoc; Intention-to-treat analysis; Gastroenterology; Surgery; Colonoscopy; Chemotherapy; Disease; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002861304,0.0006093459,0.002154637,0.0001960766,0.0003033295,0.001002979,0.0004349613,0.0006938349,0.003401644],"category_scores_gemma":[0.001768246,0.0002365161,0.001912409,0.0004780566,0.0004221244,0.0005373763,0.0003859552,0.001510109,0.0004732623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129013,"about_ca_system_score_gemma":0.001174253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931192,"about_ca_topic_score_gemma":0.001883079,"domain_scores_codex":[0.9990544,0.0004941624,0.00007544422,0.00009502008,0.0001735562,0.0001075638],"domain_scores_gemma":[0.998812,0.0003675701,0.0003959977,0.00009095074,0.0001140019,0.0002196149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7368803,0.005775067,0.01826497,0.002912445,0.007718436,0.0002021476,0.000191076,0.002649502,0.01640148,0.0003907967,0.007118142,0.2014956],"study_design_scores_gemma":[0.3858904,0.4194567,0.1434889,0.0007455096,0.01628696,0.00102498,0.000187648,0.003421569,0.01193326,0.0008112293,0.0166171,0.0001356892],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726002,0.01843553,0.0004816848,0.0006237116,0.0001101284,0.0007442941,0.002642233,0.0000868733,0.004275274],"genre_scores_gemma":[0.992432,0.003025544,0.0004839271,0.000524661,0.0001630694,0.0003674198,0.002227094,0.00001685861,0.0007594247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003401644,"threshold_uncertainty_score":0.01513219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103251426829551,"score_gpt":0.2874358644051851,"score_spread":0.27711072172223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}