{"id":"W4316077772","doi":"10.14309/01.ajg.0000859652.48283.6d","title":"S753 Mirikizumab Significantly Improves Abdominal Pain in Patients With Moderately-to-Severely Active Ulcerative Colitis: Results From the Phase 3 LUCENT-1 Induction and LUCENT-2 Maintenance Studies","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Abdominal pain; Placebo; Randomized controlled trial; Internal medicine; Gastroenterology; Adverse effect; Phases of clinical research; Clinical endpoint; Clinical trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001160258,0.0007497636,0.001566681,0.000264769,0.0002513406,0.0005573284,0.0005414772,0.0005321829,0.002936139],"category_scores_gemma":[0.0007334335,0.0002729126,0.001417681,0.000349949,0.0004343077,0.0004929979,0.0002501608,0.001428448,0.0004879129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004381325,"about_ca_system_score_gemma":0.0006138916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007274782,"about_ca_topic_score_gemma":0.002594867,"domain_scores_codex":[0.9996618,0.0001470182,0.0000399845,0.0000423933,0.00005333354,0.00005536827],"domain_scores_gemma":[0.9995547,0.00009058185,0.0001302996,0.00002789573,0.00003486338,0.000161571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6222675,0.01663453,0.0106576,0.002995397,0.00329076,0.0002861625,0.0002442,0.000924503,0.067434,0.0001345285,0.005136041,0.2699948],"study_design_scores_gemma":[0.3636511,0.519785,0.1004933,0.0002321229,0.0026881,0.0005320668,0.00009821131,0.0009956536,0.006342923,0.0001320217,0.004978059,0.00007139855],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806325,0.01542291,0.000259557,0.0005520654,0.0001296154,0.0005375118,0.0007437419,0.0001082441,0.001613821],"genre_scores_gemma":[0.99174,0.00466767,0.0007053391,0.0006079797,0.0001672228,0.000228826,0.001032184,0.00001285552,0.0008380028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002936139,"threshold_uncertainty_score":0.009822309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007834119524983191,"score_gpt":0.2400743408680949,"score_spread":0.2322402213431117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}