{"id":"W4316081714","doi":"10.14309/01.ajg.0000859880.63738.dd","title":"S810 Efficacy Outcomes by Symptom-Based Response Status After Induction: Week-48 Results from the GALAXI 1 Trial of Guselkumab in Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Randomized controlled trial; Clinical trial; Plaque psoriasis; Internal medicine; Surgery; Dermatology; Psoriasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002334104,0.0008982937,0.001846969,0.0002748786,0.0002520901,0.0007276263,0.0004945229,0.00101193,0.005770223],"category_scores_gemma":[0.001566244,0.0003086392,0.002084683,0.0002892287,0.0006585123,0.000649375,0.0004387661,0.002448729,0.0009520806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005088448,"about_ca_system_score_gemma":0.0005916638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003117322,"about_ca_topic_score_gemma":0.0008708345,"domain_scores_codex":[0.9989766,0.0006264729,0.00006146057,0.0001181441,0.00008216321,0.0001351478],"domain_scores_gemma":[0.9986265,0.0003813885,0.0004877461,0.000130652,0.00007459363,0.0002991737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9487633,0.005320021,0.005111569,0.000838877,0.001876051,0.00004474627,0.00008520674,0.0006517949,0.00509346,0.0001183058,0.002266817,0.02983],"study_design_scores_gemma":[0.6553437,0.2838935,0.05186378,0.0001489998,0.002890942,0.0001006439,0.00006890392,0.0007327439,0.00191638,0.0003309539,0.00266251,0.00004700242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906594,0.004001589,0.0001971375,0.0005134845,0.0001121404,0.0006002936,0.001411167,0.00005628554,0.002448483],"genre_scores_gemma":[0.9913742,0.001356542,0.0003817088,0.0007007528,0.0002800626,0.001012382,0.002326131,0.00001965253,0.002548496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005770223,"threshold_uncertainty_score":0.01930338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007035568920686245,"score_gpt":0.2406881326318469,"score_spread":0.2336525637111606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}