{"id":"W4316081871","doi":"10.14309/01.ajg.0000859528.76845.26","title":"S722 Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Active Ulcerative Colitis Receiving 16 Weeks Extended Induction Treatment Followed by 52 Weeks Maintenance Treatment in U-ACHIEVE/U-ACCOMPLISH Trials","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Clinical endpoint; Clinical trial; Internal medicine; Randomized controlled trial; Gastroenterology; Adverse effect; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003612799,0.0005869796,0.002232926,0.0002901974,0.0002859094,0.001093779,0.0004180223,0.000588707,0.003517654],"category_scores_gemma":[0.00213099,0.0003104314,0.002195434,0.0005740088,0.0004069942,0.0007108312,0.0003135587,0.001366082,0.0004561861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007221121,"about_ca_system_score_gemma":0.00102363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769271,"about_ca_topic_score_gemma":0.002060865,"domain_scores_codex":[0.9987452,0.0007180349,0.0001033917,0.0001607376,0.0001318975,0.0001407546],"domain_scores_gemma":[0.9986766,0.0004060935,0.0005199481,0.00008243282,0.00009984859,0.0002150609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.820794,0.002854033,0.0258718,0.003879112,0.009086018,0.0001547365,0.0001376992,0.002565152,0.008546484,0.0002708972,0.004065025,0.1217751],"study_design_scores_gemma":[0.5438067,0.2909384,0.1296117,0.0009943456,0.01285355,0.0009118305,0.0001725613,0.003737988,0.004843794,0.0006789176,0.01133147,0.0001188911],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818793,0.01250719,0.0003360408,0.0004162697,0.00007516827,0.0007513743,0.001548526,0.00006991083,0.002416296],"genre_scores_gemma":[0.9946634,0.001894068,0.0004420141,0.0002545039,0.00007379221,0.0004471059,0.00144522,0.000009510472,0.0007704307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003612799,"threshold_uncertainty_score":0.01910657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01655404697256937,"score_gpt":0.2808870690300459,"score_spread":0.2643330220574766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}