{"id":"W4316084375","doi":"10.14309/01.ajg.0000857172.24140.48","title":"S133 An Open-Label Study (ECOSPOR IV) to Evaluate the Safety, Efficacy and Durability of SER-109, an Investigational Oral Microbiome Therapeutic, in Adults With Recurrent Clostridioides difficile Infection (rCDI)","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Clostridium difficile; Cohort; Antibiotics; Gastroenterology; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312547,0.0008993478,0.0009937973,0.0001949663,0.0004270585,0.0005028014,0.0005068323,0.0009715544,0.003483616],"category_scores_gemma":[0.0006806682,0.0003185834,0.000702167,0.000281109,0.0008252949,0.0003760228,0.0003003342,0.001239967,0.0004619454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001591379,"about_ca_system_score_gemma":0.00292894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01124759,"about_ca_topic_score_gemma":0.02490289,"domain_scores_codex":[0.9995205,0.0001995175,0.00002189096,0.00007990567,0.00006613877,0.0001119673],"domain_scores_gemma":[0.9991516,0.0001084933,0.0002076332,0.00006395715,0.00009625474,0.0003721688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8793771,0.03522336,0.02444911,0.0006387383,0.0008502799,0.0001602993,0.000253765,0.000337396,0.01558497,0.0001074886,0.00188884,0.04112879],"study_design_scores_gemma":[0.3315177,0.5874605,0.07480203,0.00006830458,0.0005952354,0.0001482746,0.0001180589,0.0004238879,0.002420181,0.00007188914,0.002347684,0.00002634135],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996677,0.0004851871,0.00008707309,0.00009839657,0.00002439054,0.001209397,0.00075524,0.00001559893,0.0006477749],"genre_scores_gemma":[0.9941835,0.000554978,0.0006464944,0.0003477751,0.00008163606,0.0009083195,0.001615116,0.000005631787,0.001656547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01124759,"threshold_uncertainty_score":0.02236426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04272856787115988,"score_gpt":0.3485133610110331,"score_spread":0.3057847931398732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}