{"id":"W4316085111","doi":"10.14309/01.ajg.0000861396.81403.cf","title":"S1189 Safety and Efficacy of Oral TLR8 Agonist, Selgantolimod, in Viremic Adult Patients With Chronic Hepatitis B","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; HBsAg; Internal medicine; HBeAg; Placebo; Gastroenterology; Clinical endpoint; Adverse effect; Tenofovir alafenamide; Agonist; Immunology; Randomized controlled trial; Hepatitis B virus; Viral load; Receptor; Pathology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006214508,0.0003768631,0.0008716878,0.0001813607,0.0001827351,0.0003704517,0.000202411,0.0006227653,0.003644674],"category_scores_gemma":[0.0007482786,0.0001772614,0.0005126687,0.0001572961,0.0002423132,0.000315779,0.0001430977,0.000773773,0.0005572076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033263,"about_ca_system_score_gemma":0.0003728797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002125194,"about_ca_topic_score_gemma":0.0004228486,"domain_scores_codex":[0.9997932,0.0001102072,0.00002722797,0.00002246013,0.00002470631,0.00002227364],"domain_scores_gemma":[0.999599,0.0001030042,0.0001260502,0.00002113235,0.00003570289,0.0001149809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6069528,0.01653364,0.02461683,0.001312675,0.001092286,0.0003641209,0.0001862314,0.001103135,0.05240485,0.0001531229,0.002915241,0.292365],"study_design_scores_gemma":[0.298813,0.6136276,0.07104346,0.0001718923,0.0007970736,0.0008684371,0.0001154513,0.00183055,0.007057439,0.0001744312,0.005464921,0.00003580172],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946114,0.003289639,0.0001902365,0.0002591017,0.00006484735,0.0001904683,0.0003232655,0.00003457813,0.001036485],"genre_scores_gemma":[0.9966422,0.001213925,0.0003438985,0.0003466541,0.0001170137,0.0001824253,0.0004419927,0.000004865087,0.0007068632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003644674,"threshold_uncertainty_score":0.01219267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005486507459056695,"score_gpt":0.2333016799500793,"score_spread":0.2278151724910226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}