{"id":"W4316086213","doi":"10.14309/01.ajg.0000902192.33099.5a","title":"S747 Mirikizumab Improves Mental and Physical Health Outcomes in Patients With Moderately to Severely Active Ulcerative Colitis: Results From the Phase 3 LUCENT-1 Induction and LUCENT-2 Maintenance Studies","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Internal medicine; Placebo; Randomized controlled trial; Gastroenterology; Physical therapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131592,0.0004802374,0.001191139,0.0001956018,0.0002081336,0.0004561978,0.0003930778,0.0004468437,0.002200626],"category_scores_gemma":[0.0008047589,0.0002066958,0.001137429,0.0003019422,0.0003771366,0.0003359906,0.0002184384,0.0008571763,0.0003089257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070678,"about_ca_system_score_gemma":0.0005365699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000563464,"about_ca_topic_score_gemma":0.001700978,"domain_scores_codex":[0.9996294,0.0002044493,0.00004170302,0.00003572952,0.00004797769,0.00004070792],"domain_scores_gemma":[0.9995415,0.0001046686,0.000154916,0.00002792608,0.0000429881,0.0001280446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6752357,0.01239392,0.03413883,0.002664677,0.003872293,0.0002313844,0.0002180851,0.0006538618,0.03112208,0.0001074696,0.002942111,0.2364197],"study_design_scores_gemma":[0.3022215,0.436303,0.2461521,0.0003149467,0.004368198,0.0004719927,0.0001371067,0.001055693,0.004349105,0.0001654924,0.004396021,0.00006469723],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867742,0.01111138,0.0001350995,0.0003701283,0.00007863708,0.0002998142,0.0004102832,0.00002558622,0.0007949395],"genre_scores_gemma":[0.9935756,0.003900507,0.0004799277,0.000467316,0.0001495225,0.0002415244,0.000684743,0.000004685905,0.0004961684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200626,"threshold_uncertainty_score":0.007361829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008671900497495425,"score_gpt":0.2711563075406753,"score_spread":0.2624844070431799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}