{"id":"W4316086233","doi":"10.14309/01.ajg.0000859504.35531.82","title":"S716 Induction Combination Therapy With Guselkumab and Golimumab Followed by Guselkumab Monotherapy Maintenance: Results of the Phase 2a, Randomized, Double-Blind, Proof-of-Concept VEGA Study","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Combination therapy; Internal medicine; Randomized controlled trial; Maintenance therapy; Surgery; Refractory (planetary science); Golimumab; Intention-to-treat analysis; Clinical trial; Gastroenterology; Adalimumab; Tumor necrosis factor alpha; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001754536,0.001169908,0.003323955,0.0004256423,0.0004058569,0.001044399,0.0008821805,0.001261554,0.003644891],"category_scores_gemma":[0.0009591975,0.0006816909,0.001683962,0.0004617484,0.001201358,0.00108842,0.0004192415,0.003144882,0.001037668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007395691,"about_ca_system_score_gemma":0.001178706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008595655,"about_ca_topic_score_gemma":0.0016562,"domain_scores_codex":[0.999189,0.0004138415,0.00004804981,0.0001234205,0.0000691056,0.0001566506],"domain_scores_gemma":[0.9992771,0.0001657867,0.0001740878,0.00007858883,0.00004373489,0.0002608412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9339284,0.02124701,0.0008126979,0.00044427,0.000762339,0.0000428966,0.00006405048,0.0003569544,0.009467113,0.00007642312,0.0006047357,0.03219318],"study_design_scores_gemma":[0.6381992,0.3558393,0.003580198,0.00002821044,0.0003907335,0.00005452339,0.00002415145,0.000339866,0.0009187385,0.000059382,0.0005491888,0.00001652954],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954166,0.002046912,0.0003234781,0.0002440922,0.0001380065,0.0008340292,0.0004001807,0.00007286652,0.0005238614],"genre_scores_gemma":[0.9925253,0.001984317,0.001117135,0.0004728601,0.0002487111,0.001487367,0.0007584274,0.0000200531,0.001385792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003644891,"threshold_uncertainty_score":0.01219332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105226348308446,"score_gpt":0.3101103659711639,"score_spread":0.2890581024880794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}