{"id":"W4316086242","doi":"10.14309/01.ajg.0000859496.71797.43","title":"S714 52-Week Risankizumab Subcutaneous Maintenance Dosing Is Efficacious and Well Tolerated in Patients With Moderate to Severe Crohn’s Disease Who Had Delayed Response to 12-Weeks IV Risankizumab Induction","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Dosing; Maintenance therapy; Placebo; Clinical endpoint; Internal medicine; Crohn's disease; Gastroenterology; Clinical trial; Abdominal pain; Phases of clinical research; Surgery; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004695783,0.0003108555,0.00079021,0.0001144415,0.0001446087,0.0003231508,0.0001699331,0.0003498889,0.001246487],"category_scores_gemma":[0.0004931361,0.0001794739,0.0004258379,0.0001211703,0.0002144839,0.000278307,0.0001097851,0.0006317144,0.0002753198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002255834,"about_ca_system_score_gemma":0.0002683116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003186663,"about_ca_topic_score_gemma":0.0009460327,"domain_scores_codex":[0.9998688,0.00004679421,0.0000157692,0.00001985242,0.00002421785,0.00002468974],"domain_scores_gemma":[0.9997476,0.00005812564,0.00007940931,0.00001730917,0.00001470896,0.00008300584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3297997,0.01182194,0.1557553,0.000967695,0.0008602434,0.002115776,0.0005481482,0.001386578,0.1498312,0.0001807416,0.0036894,0.3430434],"study_design_scores_gemma":[0.06794239,0.4555027,0.446871,0.0001007661,0.0006300781,0.003168073,0.0002130217,0.003998366,0.01563708,0.0001075386,0.005771861,0.00005713374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984868,0.0008618408,0.00008649244,0.00008313995,0.00001160312,0.00004815609,0.00005289981,0.00001882878,0.0003503099],"genre_scores_gemma":[0.9991661,0.0001896462,0.0001795388,0.00007796926,0.00002188988,0.00001970016,0.0001154422,0.000001867341,0.000227753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246487,"threshold_uncertainty_score":0.004169881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00394685683907133,"score_gpt":0.2016452075006002,"score_spread":0.1976983506615289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}