{"id":"W4316086246","doi":"10.14309/01.ajg.0000859488.03460.db","title":"S712 Benefits of High versus Low Dose Upadacitinib as Maintenance Treatment in Ulcerative Colitis Patients Who Were Responders to 8-week Induction with Upadacitinib: Results From the U-ACHIEVE Phase 3 Maintenance Trial","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Maintenance therapy; Internal medicine; Post-hoc analysis; Population; Ulcerative colitis; Placebo; Gastroenterology; Post hoc; Maintenance dose; Clinical trial; Phases of clinical research; Surgery; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001792257,0.0005079168,0.001873715,0.000180754,0.0002255109,0.0008355006,0.0003797021,0.0006271632,0.00233967],"category_scores_gemma":[0.001203626,0.0002534834,0.001896956,0.00034996,0.0003892994,0.0004845922,0.0002701199,0.001528607,0.0003288375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004924554,"about_ca_system_score_gemma":0.0006676246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004798684,"about_ca_topic_score_gemma":0.001667669,"domain_scores_codex":[0.9994465,0.0003195054,0.00003709052,0.00006915519,0.00006109038,0.00006670051],"domain_scores_gemma":[0.9992043,0.0002471802,0.0002246643,0.00006902827,0.00005667016,0.0001980992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9311787,0.003252782,0.007080612,0.000695752,0.002493458,0.00006247429,0.00005899016,0.0008615546,0.00621421,0.00006618175,0.001199622,0.04683565],"study_design_scores_gemma":[0.5581907,0.3603288,0.06765793,0.0001571554,0.005688798,0.0002829823,0.00009318445,0.002026056,0.003009283,0.0001956451,0.002319121,0.00005030334],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956686,0.002542674,0.0001163555,0.0001738836,0.00004732842,0.0002502289,0.0005224737,0.00002333292,0.0006550839],"genre_scores_gemma":[0.9969406,0.0008061279,0.0002802286,0.0002400285,0.00008603225,0.0002260709,0.0008465936,0.000006068276,0.000568334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233967,"threshold_uncertainty_score":0.00947845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173366021727807,"score_gpt":0.2516757390372252,"score_spread":0.2399420788199472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}