{"id":"W4316086281","doi":"10.14309/01.ajg.0000859584.83560.ef","title":"S736 Efficacy and Safety of Upadacitinib Induction Therapy in Patients With Moderately to Severely Active Crohn’s Disease: Results From a Randomized Phase 3 U-EXCEL Study","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Gastroenterology; Colonoscopy; Demographics; Phases of clinical research; Crohn's disease; Randomized controlled trial; Clinical trial; Abdominal pain; Surgery; Disease; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001258351,0.0007123353,0.001859,0.0002791135,0.0002658303,0.0009434893,0.0005063455,0.0008689149,0.003564585],"category_scores_gemma":[0.0009338061,0.0003424202,0.00116749,0.0005219416,0.0005043477,0.0005316969,0.000281987,0.001394965,0.0006360551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004489484,"about_ca_system_score_gemma":0.001018991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006319212,"about_ca_topic_score_gemma":0.001723886,"domain_scores_codex":[0.9995211,0.000259208,0.00003885209,0.0000503338,0.00004758388,0.00008297801],"domain_scores_gemma":[0.9994318,0.0001227717,0.0001743913,0.00004328548,0.0000440257,0.0001836181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9087939,0.01273675,0.003492878,0.0008326904,0.00131886,0.00007507906,0.00006149487,0.0005761423,0.008794708,0.0000861441,0.001308403,0.06192293],"study_design_scores_gemma":[0.7685241,0.2087326,0.0170949,0.00008816734,0.001241676,0.0001474836,0.00004613046,0.0008287744,0.001653871,0.00008998418,0.001520849,0.00003162814],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917463,0.003961815,0.0004015377,0.0002453626,0.00007294845,0.001599081,0.0007582312,0.00007906798,0.001135503],"genre_scores_gemma":[0.9935829,0.00171787,0.0009618688,0.0004803784,0.00009951094,0.001314454,0.0009416706,0.00001367642,0.0008877311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003564585,"threshold_uncertainty_score":0.01192474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007361071910053741,"score_gpt":0.2467511888128089,"score_spread":0.2393901169027552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}