{"id":"W4316087129","doi":"10.14309/01.ajg.0000858200.17525.4a","title":"S390 Efficacy and Safety of On-Demand Vonoprazan versus Placebo in the Treatment of Heartburn in Symptomatic Nonerosive Reflux Disease (NERD) Patients: A Phase 2 Randomized Controlled Trial","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Heartburn; Nerd; Placebo; Internal medicine; Clinical endpoint; Gastroenterology; Randomized controlled trial; Antacid; Reflux; Drug; Disease; Pharmacology; GERD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001738192,0.002118821,0.003985545,0.0005550557,0.0005149176,0.001461849,0.001276647,0.003741913,0.01777871],"category_scores_gemma":[0.001929833,0.0008981824,0.002488806,0.0004551488,0.001028233,0.00145472,0.0004689307,0.002853067,0.001940227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006958363,"about_ca_system_score_gemma":0.001117859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000670865,"about_ca_topic_score_gemma":0.001549024,"domain_scores_codex":[0.9992004,0.0004018628,0.00005701296,0.0001619738,0.00007624718,0.0001024676],"domain_scores_gemma":[0.9990496,0.0002990748,0.0002138827,0.00006123097,0.00008178582,0.0002943267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9843801,0.003815887,0.0001798855,0.001234324,0.0009267452,0.0000275981,0.00002775787,0.00009121338,0.001228181,0.00006949691,0.0006529502,0.007365905],"study_design_scores_gemma":[0.9704113,0.02802234,0.0004933564,0.00005113083,0.0003329116,0.0000154179,0.00000972076,0.0001325721,0.0001039747,0.00007035519,0.0003484084,0.000008443256],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558671,0.01784801,0.0008506218,0.001683391,0.001958725,0.01105901,0.003855953,0.0003118175,0.006565384],"genre_scores_gemma":[0.9669485,0.006421705,0.002084083,0.002376495,0.001309587,0.01230941,0.002142028,0.00004868966,0.00635955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01777871,"threshold_uncertainty_score":0.05947566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111860861764267,"score_gpt":0.3011514994689284,"score_spread":0.2900328908512858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}