{"id":"W4316341716","doi":"10.20944/preprints202301.0247.v1","title":"Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial Dependent Apoptosis in GBM Cells which is Regulated by Autophagy","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Shahid Beheshti University of Medical Sciences","keywords":"Autophagy; Temozolomide; Programmed cell death; Apoptosis; Pharmacology; Cancer research; Viability assay; Medicine; Chemistry; Biochemistry; Glioblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032407,0.0002845312,0.0005725122,0.000295457,0.0001351212,0.0001616819,0.0001469278,0.0001759657,0.0006740636],"category_scores_gemma":[0.0000625527,0.0001122548,0.0003536243,0.0002644511,0.000161135,0.0001694755,0.0001567737,0.0005245933,0.0001155752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002829,"about_ca_system_score_gemma":0.0003715227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009261377,"about_ca_topic_score_gemma":0.003092059,"domain_scores_codex":[0.9998838,0.00001814907,0.00001616208,0.00001566695,0.00003148783,0.00003468368],"domain_scores_gemma":[0.9999653,0.000004059672,0.000008524926,0.000004249023,0.0000049499,0.00001276255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00224173,0.0005130763,0.001238599,0.0002650371,0.00008610834,0.0001566742,0.00005144815,0.000211962,0.9848994,0.0001233331,0.0003957081,0.009816983],"study_design_scores_gemma":[0.0003303428,0.007339292,0.02212557,0.00001858939,0.0001253591,0.0004255784,0.00009566532,0.001326771,0.9644186,0.00009830085,0.003682747,0.00001325138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960724,0.002485561,0.0003700299,0.00007922084,0.00004199253,0.0000358885,0.0002360525,0.00004307696,0.000635705],"genre_scores_gemma":[0.9961247,0.001731031,0.0006900805,0.00005880123,0.00001504976,0.00005987607,0.0004245758,0.000004654047,0.0008912162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009261377,"threshold_uncertainty_score":0.002254963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176805255135781,"score_gpt":0.3062844085009712,"score_spread":0.2645163559496134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}