{"id":"W4316341716","doi":"10.20944/preprints202301.0247.v1","title":"Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial Dependent Apoptosis in GBM Cells which is Regulated by Autophagy","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Shahid Beheshti University of Medical Sciences","keywords":"Autophagy; Temozolomide; Programmed cell death; Apoptosis; Pharmacology; Cancer research; Viability assay; Medicine; Chemistry; Biochemistry; Glioblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006031854,0.0005148107,0.0006162394,0.0002065046,0.00009192657,0.00006240448,0.0005361531,0.0009986549,0.0001053294],"category_scores_gemma":[0.0002813372,0.0005862488,0.0001515796,0.0002363548,0.0001071827,0.00001287331,0.001739904,0.0007181597,0.0001041069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044538,"about_ca_system_score_gemma":0.0003099893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313584,"about_ca_topic_score_gemma":0.0004329674,"domain_scores_codex":[0.9964448,0.0002920563,0.000742849,0.001635,0.0003795171,0.0005057497],"domain_scores_gemma":[0.9981223,0.00004631239,0.0004162506,0.001019121,0.0002170428,0.0001790235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001825739,0.0001667993,0.008275395,0.000136529,0.0001582441,3.128389e-7,0.0006035719,0.0002866863,0.9786552,0.00001580068,0.01078626,0.0007326326],"study_design_scores_gemma":[0.001818281,0.00005100611,0.03632659,0.0001067176,0.00007417089,0.000002683149,0.0001425672,0.0001095546,0.9439485,0.0003580315,0.01646492,0.0005969662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988215,0.0007527799,0.00007970866,0.0005401561,0.008791721,0.0009750237,0.0002493682,0.00007731005,0.0003189053],"genre_scores_gemma":[0.9882188,0.002644403,0.000182698,0.00017765,0.002175255,0.0003202554,0.0007828517,0.0000982932,0.005399812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03470669,"threshold_uncertainty_score":0.9996589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176805255135781,"score_gpt":0.3062844085009712,"score_spread":0.2645163559496134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}