{"id":"W4316464831","doi":"10.3390/genes14010216","title":"Distinct Roles of Histone Lysine Demethylases and Methyltransferases in Developmental Eye Disease","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Eye Institute","keywords":"Biology; Genetics; Histone methyltransferase; Methyltransferase; Epigenetics; Demethylase; Histone; Phenotype; Histone methylation; Gene; Methylation; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002689348,0.0002963058,0.0002682462,0.0008740961,0.000183078,0.0002233073,0.0001805683,0.000327762,0.001003551],"category_scores_gemma":[0.000565043,0.0001239427,0.0002045718,0.0002371778,0.000340713,0.000204605,0.0004205979,0.0001807451,0.0001278627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681919,"about_ca_system_score_gemma":0.00008816316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003846716,"about_ca_topic_score_gemma":0.0006873092,"domain_scores_codex":[0.9997671,0.00004209049,0.0000417387,0.00005859294,0.00005618232,0.00003437387],"domain_scores_gemma":[0.9998022,0.0000630575,0.00004657526,0.00002210369,0.00002106278,0.00004503354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001063151,0.00008367014,0.2676527,0.0001070322,0.0001383755,0.01032608,0.0005084309,0.0003597239,0.6954006,0.001225257,0.0001634959,0.02297154],"study_design_scores_gemma":[0.00008556,0.0004812721,0.8359509,0.00003453193,0.0001741669,0.06537911,0.0003639251,0.001405844,0.09127001,0.001253383,0.003570812,0.00003050218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975752,0.001144466,0.000528911,0.00004476271,0.000004416922,0.000004682177,0.00008125464,0.000008776537,0.0006075615],"genre_scores_gemma":[0.9989631,0.0002882675,0.000442114,0.00002863485,0.000005418527,0.00000282493,0.00007423648,0.000004125124,0.0001913088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003551,"threshold_uncertainty_score":0.003357232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194392477822963,"score_gpt":0.2994001343591799,"score_spread":0.2799608865768836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}