{"id":"W4316464831","doi":"10.3390/genes14010216","title":"Distinct Roles of Histone Lysine Demethylases and Methyltransferases in Developmental Eye Disease","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Eye Institute","keywords":"Biology; Genetics; Histone methyltransferase; Methyltransferase; Epigenetics; Demethylase; Histone; Phenotype; Histone methylation; Gene; Methylation; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420022,0.0001005129,0.0001214809,0.00008423364,0.00003484033,0.000006396878,0.00006220139,0.00004625892,0.000008724536],"category_scores_gemma":[0.00008825082,0.00009694711,0.00003600499,0.0001522398,0.00006914045,0.000002533799,0.00004341352,0.00002231953,0.000002561239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006800765,"about_ca_system_score_gemma":0.00004746202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003214512,"about_ca_topic_score_gemma":0.0002850656,"domain_scores_codex":[0.9993281,0.00004476251,0.0001863341,0.0002166323,0.00008920137,0.000135005],"domain_scores_gemma":[0.9997452,0.00002331621,0.00003257396,0.0001037328,0.00003100028,0.00006414086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004580707,0.00002869037,0.2095774,0.00003262448,0.00001475291,0.000003917343,0.00004315571,0.00007526655,0.7719891,0.00001438033,0.00001996236,0.01815492],"study_design_scores_gemma":[0.0002294513,0.0000432029,0.4104594,0.00001002892,0.00001308944,1.10763e-7,0.00005592525,0.0000355664,0.5849671,0.0001548638,0.003929354,0.0001018988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987346,0.01204558,0.000277848,0.0000780412,0.00004095176,0.00008580051,0.00006506893,0.000009859634,0.00005088164],"genre_scores_gemma":[0.995611,0.002983927,0.0008965813,0.00001314823,0.00004383627,0.00001705839,0.0002580903,0.00001304845,0.000163284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.200882,"threshold_uncertainty_score":0.3953389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194392477822963,"score_gpt":0.2994001343591799,"score_spread":0.2799608865768836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}