{"id":"W4316494230","doi":"10.3389/fnmol.2022.1078441","title":"Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases","year":2023,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Autophagy; Neurodegeneration; Neuroscience; Biology; Amyotrophic lateral sclerosis; Mechanism (biology); Disease; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007797615,0.0007963763,0.002359904,0.001031131,0.0001884403,0.00007698566,0.0007966066,0.0004078806,0.000003499234],"category_scores_gemma":[0.0008662064,0.0007812333,0.000744467,0.002139693,0.0002555986,0.0001736507,0.0001960724,0.0008506648,0.000002464644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004463395,"about_ca_system_score_gemma":0.001035269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005272163,"about_ca_topic_score_gemma":0.000001894252,"domain_scores_codex":[0.9940547,0.00109932,0.001223596,0.00166598,0.0009459952,0.001010404],"domain_scores_gemma":[0.9977616,0.0002434605,0.0008922733,0.0006976434,0.0001215557,0.0002834306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001645862,0.009962631,0.00007450052,0.04535524,0.00275809,0.009665019,0.004361833,0.03457133,0.4382711,0.003295644,0.001673315,0.4483654],"study_design_scores_gemma":[0.01663083,0.00661921,0.000489086,0.01682412,0.006508809,0.000208242,0.001282977,0.8219408,0.05743742,0.05874192,0.007214623,0.006101997],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.001007305,0.3545859,0.636197,0.00007592719,0.001201021,0.006327959,0.000329544,0.0002467298,0.0000286349],"genre_scores_gemma":[0.07858709,0.8489481,0.04607129,0.01423743,0.0005296588,0.006988935,0.00144399,0.002224654,0.0009688794],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7873694,"threshold_uncertainty_score":0.9994639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232167350668525,"score_gpt":0.3144791542933993,"score_spread":0.2912624192265468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}