{"id":"W4316506860","doi":"10.1038/s44161-022-00206-6","title":"TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease","year":2023,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vector Institute","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institutes of Health; Agencia Estatal de Investigación; European Research Area Network on Cardiovascular Diseases; Knut och Alice Wallenbergs Stiftelse; American Heart Association; Fundación BBVA; University of Pennsylvania; Medical Research Council; Celgene; National Institute of General Medical Sciences; Ministerio de Ciencia e Innovación; Massachusetts General Hospital; Novo Nordisk; European Social Fund; Fondation Leducq; European Regional Development Fund; European Commission; Alexander and Margaret Stewart Trust; Banco Bilbao Vizcaya Argentaria; U.S. Department of Veterans Affairs","keywords":"Haematopoiesis; Disease; Atherosclerotic cardiovascular disease; Medicine; Immunology; Biology; Internal medicine; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01180585,0.0004071001,0.001038339,0.001369781,0.0006694972,0.0001446178,0.0007113779,0.000779644,0.0001751065],"category_scores_gemma":[0.02037148,0.0003501518,0.001944996,0.003234336,0.0005863246,0.0001446524,0.0005620657,0.003884701,0.001044737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001217304,"about_ca_system_score_gemma":0.002226464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004560888,"about_ca_topic_score_gemma":0.00001812437,"domain_scores_codex":[0.9902111,0.001348572,0.000479305,0.001227257,0.004922391,0.001811317],"domain_scores_gemma":[0.9917215,0.002389483,0.00006921155,0.002105951,0.002251624,0.001462243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.02182752,0.001692888,0.174494,0.01005843,0.04033729,0.01507343,0.00177923,0.001228042,0.02518846,0.004460509,0.6605538,0.04330646],"study_design_scores_gemma":[0.02094501,0.000750886,0.6256549,0.0006733952,0.001903,0.0001757427,0.001245937,0.01357528,0.005392662,0.001787412,0.3267583,0.001137466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769667,0.01090069,0.0003976713,0.003260948,0.0003117271,0.006093962,0.0005999875,0.0006129419,0.0008553734],"genre_scores_gemma":[0.992042,0.00225633,0.0004494179,0.0003006528,0.0009467801,0.001387205,0.001182825,0.0002070441,0.00122777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.451161,"threshold_uncertainty_score":0.999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04792986906070916,"score_gpt":0.362481284601952,"score_spread":0.3145514155412428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}