{"id":"W4316506860","doi":"10.1038/s44161-022-00206-6","title":"TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease","year":2023,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vector Institute","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institutes of Health; Agencia Estatal de Investigación; European Research Area Network on Cardiovascular Diseases; Knut och Alice Wallenbergs Stiftelse; American Heart Association; Fundación BBVA; University of Pennsylvania; Medical Research Council; Celgene; National Institute of General Medical Sciences; Ministerio de Ciencia e Innovación; Massachusetts General Hospital; Novo Nordisk; European Social Fund; Fondation Leducq; European Regional Development Fund; European Commission; Alexander and Margaret Stewart Trust; Banco Bilbao Vizcaya Argentaria; U.S. Department of Veterans Affairs","keywords":"Haematopoiesis; Disease; Atherosclerotic cardiovascular disease; Medicine; Immunology; Biology; Internal medicine; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422788,0.0003022469,0.0002027434,0.0005396352,0.0002840832,0.0004450235,0.0002533015,0.0006323125,0.005446063],"category_scores_gemma":[0.0009646419,0.0002238629,0.0002634821,0.0003352696,0.0001753377,0.0002286324,0.0002607171,0.0006997059,0.0003819309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001324541,"about_ca_system_score_gemma":0.0001331419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005379756,"about_ca_topic_score_gemma":0.0005456647,"domain_scores_codex":[0.9997961,0.00005516776,0.000009888997,0.00005023695,0.00003653335,0.00005205883],"domain_scores_gemma":[0.999386,0.0001099843,0.0002045134,0.0001180452,0.0000511422,0.0001302955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00318002,0.0003346228,0.8689698,0.00004494324,0.0003491966,0.001558369,0.00007896861,0.0003346774,0.09923425,0.001001518,0.001008584,0.02390514],"study_design_scores_gemma":[0.0000528252,0.0005417964,0.9878296,0.00001205275,0.0001818668,0.002853974,0.00005905893,0.00109906,0.005888684,0.0006161194,0.0008539588,0.000011002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974073,0.0002271971,0.0006091221,0.00009098875,0.00002164545,0.00000614042,0.0002433808,0.00002995976,0.001364317],"genre_scores_gemma":[0.9985104,0.000123128,0.0002502469,0.00003573905,0.00004067846,0.00000439115,0.0001442077,0.000009856483,0.0008813515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005446063,"threshold_uncertainty_score":0.01821893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04792986906070916,"score_gpt":0.362481284601952,"score_spread":0.3145514155412428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}