{"id":"W4316661384","doi":"10.1172/jci163498","title":"BMX controls 3βHSD1 and sex steroid biosynthesis in cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"U.S. Army Medical Research and Development Command; Astellas Pharma; National Cancer Institute; National Institutes of Health; Case Western Reserve University; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Aromatase; Androgen; Endocrinology; Prostate cancer; Androgen receptor; Internal medicine; Testosterone (patch); Intracrine; Cancer research; Biology; Cancer; Medicine; Hormone; Receptor; Breast cancer; Paracrine signalling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061738,0.0002346892,0.0001829178,0.0002127155,0.0002171107,0.0003899862,0.0002379343,0.0002164683,0.00344039],"category_scores_gemma":[0.0001208528,0.0001588663,0.0001653425,0.0001388813,0.000238491,0.0001360033,0.000238197,0.0003641607,0.0004967705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988401,"about_ca_system_score_gemma":0.0002768272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008303754,"about_ca_topic_score_gemma":0.001257527,"domain_scores_codex":[0.9998515,0.0000262298,0.000008169141,0.00004221183,0.00003701631,0.00003479526],"domain_scores_gemma":[0.9999061,0.000008577328,0.00003584991,0.000008501152,0.000006749445,0.0000341503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006091572,0.00007608357,0.001306229,0.00004169119,0.000009633307,0.00007278113,0.00002478853,0.00008351491,0.989632,0.0004635837,0.0003306909,0.007349811],"study_design_scores_gemma":[0.0001291352,0.0009769532,0.07961154,0.00001901815,0.00004543295,0.00075187,0.0001290634,0.001478113,0.8927568,0.0004216603,0.02366355,0.00001687795],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845176,0.007471006,0.002415877,0.0003878567,0.000128121,0.00004496089,0.000702219,0.0002494798,0.004082819],"genre_scores_gemma":[0.9891695,0.002068894,0.001052941,0.0001170936,0.00002004589,0.00004024695,0.0005345244,0.00003377736,0.006963114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00344039,"threshold_uncertainty_score":0.01150924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1964156680675548,"score_gpt":0.4765284341384812,"score_spread":0.2801127660709263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}