{"id":"W4316663717","doi":"10.1002/mds.29318","title":"Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting <scp>α‐Synuclein</scp>","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Lundbeckfonden","keywords":"Clinical trial; Clinical neurology; Medicine; Neuroscience; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003443907,0.0004197372,0.0009458086,0.0002674474,0.0003140187,0.0000677025,0.0001720812,0.0002519336,0.0003846558],"category_scores_gemma":[0.003730382,0.0003549674,0.0006287712,0.0005164218,0.00005625302,0.0001100916,0.0001379195,0.0005480099,0.0005375706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803574,"about_ca_system_score_gemma":0.0001091458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000152011,"about_ca_topic_score_gemma":0.00005431975,"domain_scores_codex":[0.9959303,0.000481574,0.00113926,0.0008435552,0.0007956767,0.0008096512],"domain_scores_gemma":[0.9975237,0.001078804,0.0003972201,0.000508423,0.00006814529,0.0004237716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001035134,0.004969128,0.3064982,0.0003307037,0.004168931,0.0006147271,0.001563025,0.0004879248,0.00638522,0.003101483,0.5376399,0.1332056],"study_design_scores_gemma":[0.03618874,0.003641991,0.1307195,0.0008943388,0.001755821,0.000001038183,0.007091634,0.005352036,0.007134916,0.02899417,0.7774717,0.0007540936],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608384,0.0003541289,0.0001641821,0.007550051,0.001102077,0.001691882,0.00007972507,0.0005149163,0.0277046],"genre_scores_gemma":[0.9479814,0.001126529,0.0006304557,0.03511567,0.0006167729,0.0002735166,0.0003425767,0.0001705153,0.0137426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2398318,"threshold_uncertainty_score":0.9998902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1701967918097487,"score_gpt":0.4526082843705371,"score_spread":0.2824114925607885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}