{"id":"W4316663717","doi":"10.1002/mds.29318","title":"Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting <scp>α‐Synuclein</scp>","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Lundbeckfonden","keywords":"Clinical trial; Clinical neurology; Medicine; Neuroscience; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01354557,0.0006934659,0.001210719,0.0007138025,0.002784911,0.007147064,0.001024534,0.009599976,0.007439924],"category_scores_gemma":[0.04490838,0.0003652417,0.001132963,0.0005535595,0.003727029,0.007220359,0.00232571,0.01830587,0.005329171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002513818,"about_ca_system_score_gemma":0.003176369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355883,"about_ca_topic_score_gemma":0.004330764,"domain_scores_codex":[0.9924384,0.003671148,0.0006479288,0.0009317037,0.001636766,0.0006739845],"domain_scores_gemma":[0.9710217,0.01560598,0.002577966,0.0007035841,0.006766093,0.003324615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009545122,0.0001823142,0.005852064,0.00195326,0.0002791761,0.001546991,0.00438838,0.0001281489,0.00231255,0.01062323,0.7551726,0.2166068],"study_design_scores_gemma":[0.0002195519,0.0005806112,0.003129079,0.001872431,0.0002727408,0.002539346,0.006366964,0.0001585004,0.002683141,0.01454268,0.9674433,0.0001916142],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005970423,0.0504733,0.00209512,0.9049009,0.02649736,0.00008497886,0.0002919632,0.0001050114,0.00958096],"genre_scores_gemma":[0.04790131,0.03690445,0.001945688,0.8792913,0.02063345,0.0001204225,0.0002259474,0.000167841,0.01280965],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01354557,"threshold_uncertainty_score":0.07163668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1701967918097487,"score_gpt":0.4526082843705371,"score_spread":0.2824114925607885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}