{"id":"W4316813247","doi":"10.1007/s00535-023-01955-2","title":"Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases","year":2023,"lang":"en","type":"article","venue":"Journal of Gastroenterology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Cancer Institute; Medical Research Council; Centers for Disease Control and Prevention; Institut Gustave-Roussy; Deutsche Krebshilfe; World Health Organization; European Commission; Wellcome Trust; Fred Hutchinson Cancer Research Center; Deutsches Krebsforschungszentrum; Institut National de la Santé et de la Recherche Médicale; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Vetenskapsrådet; Cancer Research UK; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Microsatellite instability; Internal medicine; KRAS; Medicine; Cecum; Rectum; Oncology; Surgical oncology; Hazard ratio; Hepatology; Cancer; Sigmoid colon; Gastroenterology; Confidence interval; Biology; Allele; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510617,0.0001733758,0.0007372707,0.0003619016,0.00005622317,0.000006734494,0.00007666725,0.00005369874,0.00001455042],"category_scores_gemma":[0.0003580146,0.0001308948,0.0001476775,0.0003029651,0.0001910438,0.00006996661,0.0000925455,0.0001651054,5.088591e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052155,"about_ca_system_score_gemma":0.0001030543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001793986,"about_ca_topic_score_gemma":0.0005901954,"domain_scores_codex":[0.9986029,0.0001059908,0.0005706746,0.0001644491,0.0002948152,0.000261218],"domain_scores_gemma":[0.9984334,0.0001526136,0.0006559377,0.00006932834,0.000583488,0.0001052518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007301913,0.0003148316,0.9544058,0.0001026266,0.000911032,0.00018578,0.0006249427,0.00006121327,0.03562142,9.006861e-7,0.0001221887,0.000347325],"study_design_scores_gemma":[0.002926835,0.0138229,0.9638677,0.0002343823,0.0007455078,0.000376562,0.0004339073,0.0000855734,0.01742982,0.00002087837,0.000003894553,0.00005206689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983393,0.0009789595,0.000008501942,0.0001570746,0.0001401635,0.0003007848,0.00005046451,0.000009581903,0.00001516323],"genre_scores_gemma":[0.9995152,0.0002509811,0.00007284092,0.00005174091,0.00004547375,0.00002778594,0.00001355862,0.0000160944,0.000006265285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01819159,"threshold_uncertainty_score":0.5337734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053800679296434,"score_gpt":0.3163280733085557,"score_spread":0.2957900665155914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}