{"id":"W4316927633","doi":"10.1093/molbev/msad009","title":"Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in <i>Candida albicans</i>","year":2023,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Minnesota; Burroughs Wellcome Fund","keywords":"Biology; Antifungal drug; Candida albicans; Fluconazole; Adaptation (eye); Drug; Phenotype; Drug resistance; Genetics; Genotype; Evolutionary biology; Antifungal; Gene; Microbiology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879023,0.0003357983,0.0002562863,0.0004412041,0.0003571938,0.0006994935,0.0003832883,0.0005392244,0.001025671],"category_scores_gemma":[0.0007594607,0.0001650997,0.0003025006,0.0004378698,0.0003518015,0.0002855378,0.0006816413,0.0006834112,0.0001789762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005411211,"about_ca_system_score_gemma":0.0002688571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592695,"about_ca_topic_score_gemma":0.002156237,"domain_scores_codex":[0.9996973,0.00006611376,0.0000297676,0.0000839582,0.00006990181,0.00005292043],"domain_scores_gemma":[0.9997163,0.00009220969,0.00007853795,0.0000290389,0.00004720564,0.0000366154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007687,0.00008893888,0.01684417,0.00006396113,0.00004130677,0.0001936195,0.000152933,0.001522704,0.9673986,0.0003002283,0.00009848655,0.01309434],"study_design_scores_gemma":[0.00004008073,0.001856307,0.5993842,0.0000835558,0.0001607451,0.002455527,0.0007904037,0.01130779,0.3745595,0.000949769,0.008251587,0.000160614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978879,0.0002735946,0.0005986349,0.00004584615,0.000004782411,0.00001364045,0.0002502324,0.00002248004,0.0009029469],"genre_scores_gemma":[0.9961426,0.0003410795,0.002138959,0.0001149187,0.000006238406,0.00002510048,0.0005855385,0.00003591393,0.0006096598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592695,"threshold_uncertainty_score":0.003926098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008476052408882878,"score_gpt":0.2836484959446286,"score_spread":0.2751724435357457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}