{"id":"W4316927633","doi":"10.1093/molbev/msad009","title":"Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in <i>Candida albicans</i>","year":2023,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Minnesota; Burroughs Wellcome Fund","keywords":"Biology; Antifungal drug; Candida albicans; Fluconazole; Adaptation (eye); Drug; Phenotype; Drug resistance; Genetics; Genotype; Evolutionary biology; Antifungal; Gene; Microbiology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675939,0.00006453984,0.0001337573,0.00005125947,0.00006126378,0.000002669383,0.00002912137,0.00006594117,0.0000131592],"category_scores_gemma":[0.0001048041,0.00004592952,0.0000388171,0.0003043004,0.0002510706,0.00003030914,0.00001468747,0.0001082406,0.000006136178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004111205,"about_ca_system_score_gemma":0.00008663184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922179,"about_ca_topic_score_gemma":0.0003939368,"domain_scores_codex":[0.9993644,0.0001054042,0.0001564775,0.0001513596,0.00006234525,0.0001600473],"domain_scores_gemma":[0.9997143,0.00005705631,0.0000473429,0.000113891,0.00003449075,0.00003289682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002995838,0.00004447778,0.6781814,0.00002588869,0.00003222363,0.00001592735,0.0003777236,0.00003758123,0.303995,0.01649591,0.0002085561,0.0002858327],"study_design_scores_gemma":[0.0005156014,0.0001496453,0.9793084,0.00003482086,0.0000297578,0.000006050748,0.0004536602,0.001212394,0.01177336,0.006429947,0.00003692094,0.0000494536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943621,0.0006107321,0.002779296,0.001395474,0.00005109094,0.0002295518,0.00001574596,0.00001816318,0.0005379069],"genre_scores_gemma":[0.9996051,0.00009096377,0.00003784919,0.00009830434,0.00001730665,0.000007120655,0.00006760136,0.000003768144,0.0000720049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.301127,"threshold_uncertainty_score":0.1872951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008476052408882878,"score_gpt":0.2836484959446286,"score_spread":0.2751724435357457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}