{"id":"W4316928297","doi":"10.1172/jci166710","title":"BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Steven and Alexandra Cohen Foundation; Connecticut Children's Medical Center; Global Lyme Alliance; East Carolina University","keywords":"rpoS; Biology; Borrelia burgdorferi; Regulon; Sigma factor; rpoN; Psychological repression; Transcription (linguistics); RNA polymerase; Microbiology; Cell biology; Genetics; Regulation of gene expression; Gene; Gene expression; RNA; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415071,0.0003067346,0.000221352,0.0001647384,0.0001151322,0.0003540294,0.0001439388,0.0001944939,0.0005926927],"category_scores_gemma":[0.0001115829,0.0001990113,0.0002231326,0.00007687182,0.0002941988,0.0001723828,0.0003296325,0.0003691276,0.0004102407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001715989,"about_ca_system_score_gemma":0.0001283284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002227733,"about_ca_topic_score_gemma":0.0003986193,"domain_scores_codex":[0.999782,0.00002765502,0.00001457945,0.00007452172,0.00005544997,0.00004579692],"domain_scores_gemma":[0.9998906,0.00001066502,0.00004549268,0.00001278034,0.00001311286,0.00002738323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003410798,0.0000030627,0.0002706161,0.00001221223,0.000001495196,0.00001461749,0.000007165408,0.00001414177,0.9992157,0.00003273511,0.0000140678,0.000379986],"study_design_scores_gemma":[0.00002082081,0.0002866803,0.0667299,0.00001453146,0.00002638013,0.000409761,0.0001030648,0.001477409,0.9273031,0.0001333398,0.003482387,0.00001261402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942265,0.002055776,0.002194215,0.00007699699,0.00001943824,0.00001088461,0.0003723797,0.0001271484,0.0009166529],"genre_scores_gemma":[0.9960235,0.0003970692,0.001230566,0.00009051114,0.00001114026,0.00002155679,0.0006847145,0.00004263261,0.001498186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005926927,"threshold_uncertainty_score":0.001982689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920791187023144,"score_gpt":0.3353410682005961,"score_spread":0.2961331563303647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}