{"id":"W4317036529","doi":"10.3390/toxins15010080","title":"The Important Role of Membrane Fluidity on the Lytic Mechanism of the α-Pore-Forming Toxin Sticholysin I","year":2023,"lang":"en","type":"article","venue":"Toxins","topic":"Marine Invertebrate Physiology and Ecology","field":"Earth and Planetary Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Agencia Nacional de Promoción Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas; German Academic Exchange Service London; International Union of Biochemistry and Molecular Biology; Alexander von Humboldt-Stiftung","keywords":"Membrane fluidity; Membrane; Biophysics; Vesicle; Bilayer; Lipid bilayer; Pore-forming toxin; Lipid bilayer fusion; Chemistry; Sphingomyelin; Lytic cycle; Biochemistry; Biology; Toxin; Microbial toxins","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434465,0.0002560975,0.0002034332,0.0001418285,0.0001591562,0.0003328076,0.0001138922,0.0002342904,0.000269227],"category_scores_gemma":[0.0003373694,0.0001214565,0.0001559373,0.00007528409,0.0003946091,0.0004581299,0.0003152656,0.0003510738,0.00007194687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999673,"about_ca_system_score_gemma":0.0001222147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910039,"about_ca_topic_score_gemma":0.000111374,"domain_scores_codex":[0.9998925,0.00002691004,0.00001284928,0.0000163663,0.00002538561,0.00002593913],"domain_scores_gemma":[0.9998477,0.00005820185,0.00004910055,0.00001137785,0.00001355107,0.00002005855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005114948,0.000006153765,0.000258672,0.00001314916,0.000002945252,0.00002955873,0.00001643112,0.0001373898,0.9987887,0.00007834714,0.000003379428,0.0006141284],"study_design_scores_gemma":[0.000008240577,0.0001191422,0.004130002,0.000004525875,0.00001165798,0.0001077779,0.00003591066,0.002378969,0.992816,0.0001049469,0.0002751517,0.00000755078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982836,0.0004842133,0.0009029945,0.00004171875,0.000004449585,0.000005789112,0.00001924655,0.000009297515,0.0002487102],"genre_scores_gemma":[0.9992173,0.0003457013,0.0003163125,0.00001292224,0.000003488465,0.000005830068,0.00001771197,0.000003719654,0.00007705374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003328076,"threshold_uncertainty_score":0.001450896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442474142193575,"score_gpt":0.2017000987024634,"score_spread":0.1872753572805276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}