{"id":"W4317038833","doi":"10.21203/rs.3.rs-2408759/v1","title":"Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Departement Economie, Wetenschap en Innovatie; University of Gondar; Fonds Wetenschappelijk Onderzoek; Universiteit Antwerpen; Vlaams Supercomputer Centrum; Vlaamse regering; Instituut voor Tropische Geneeskunde","keywords":"Immunology; Medicine; Immune system; CD8; Population; TIGIT; Visceral leishmaniasis; Cellular immunity; T cell; Immunotherapy; Immunophenotyping; Virology; Leishmaniasis; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690504,0.0002046522,0.0002610337,0.0005922545,0.0003999967,0.0006177353,0.0001911218,0.0004648906,0.003485623],"category_scores_gemma":[0.002163273,0.0001561807,0.000120332,0.0005970661,0.000361981,0.0003472688,0.0002454273,0.0004527505,0.0003082443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510653,"about_ca_system_score_gemma":0.0002071277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008790256,"about_ca_topic_score_gemma":0.0005257695,"domain_scores_codex":[0.9997888,0.00006370031,0.00002093158,0.00003942716,0.00001929132,0.00006774411],"domain_scores_gemma":[0.9990383,0.0003675023,0.0003129359,0.00007466895,0.00005403188,0.0001524716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00199069,0.0001353878,0.9823465,0.00004897248,0.00004218979,0.002620978,0.0003068142,0.00006178068,0.003514755,0.0001222545,0.0005194377,0.008290121],"study_design_scores_gemma":[0.00006531954,0.0005193784,0.9931313,0.00001976133,0.00005105633,0.004524124,0.0005277026,0.0001813892,0.0003386422,0.0002311889,0.0004045266,0.000005617137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989942,0.000239003,0.00001877586,0.00006399436,0.000005670334,0.000003645268,0.00008566887,0.000002723577,0.0005862906],"genre_scores_gemma":[0.9995983,0.00008571471,0.00001718199,0.00003705507,0.00002932933,0.000002952112,0.00008973175,0.000001200266,0.0001386347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003485623,"threshold_uncertainty_score":0.01166058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07448758653219895,"score_gpt":0.3681767563309505,"score_spread":0.2936891697987516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}