{"id":"W4317039705","doi":"10.21203/rs.3.rs-2437117/v1","title":"UBE4B Phosphorylation is Essential to Stabilize p53 in Response to DNA Damage","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta","keywords":"DNA damage; Phosphorylation; Dephosphorylation; Cell biology; Cell cycle checkpoint; DNA repair; DNA; Biology; Apoptosis; Cell cycle; Cancer cell; Cancer research; Cancer; Biochemistry; Phosphatase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002109466,0.0004126799,0.0003801175,0.0003912547,0.0003707513,0.0006657122,0.0002315378,0.0005120375,0.007570854],"category_scores_gemma":[0.0003975605,0.0002012485,0.0002636636,0.0002679308,0.0002919306,0.0003840765,0.0003747994,0.0006253294,0.001934267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004458742,"about_ca_system_score_gemma":0.0002592052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931935,"about_ca_topic_score_gemma":0.0004580351,"domain_scores_codex":[0.9998363,0.00002057164,0.000007822327,0.00004009597,0.00004147145,0.00005367741],"domain_scores_gemma":[0.9998703,0.00001872943,0.0000323665,0.00002244867,0.00001927516,0.00003679583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324204,0.00009466946,0.00127921,0.0001869688,0.00003853506,0.0004467553,0.0000223958,0.0004934408,0.9796595,0.003233337,0.002062273,0.01115871],"study_design_scores_gemma":[0.0000845967,0.000140578,0.01786155,0.00001481174,0.00002653136,0.0007946841,0.00004564843,0.003179934,0.9615694,0.003145146,0.01312451,0.00001272158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475574,0.00826651,0.01437011,0.002456247,0.0007576082,0.00005353831,0.003490927,0.0008377716,0.02220992],"genre_scores_gemma":[0.9756867,0.001412875,0.00342737,0.0001438087,0.0000577891,0.00002136356,0.002223567,0.0001205491,0.01690586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007570854,"threshold_uncertainty_score":0.02532709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07659830810801026,"score_gpt":0.4269117439607366,"score_spread":0.3503134358527263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}