{"id":"W4317103528","doi":"10.3390/curroncol30010098","title":"Immune Checkpoint Glycoproteins Have Polymorphism: Are Monoclonal Antibodies Too Specific?","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Monoclonal antibody; Antibody; Immunotherapy; Epitope; Immune system; Immunology; Cancer immunotherapy; Polyclonal antibodies; Monoclonal; clone (Java method); Biology; Immune checkpoint; Medicine; Cancer research; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004518302,0.0005464804,0.001273595,0.0006122867,0.0003666287,0.001590677,0.001168608,0.003528723,0.001385106],"category_scores_gemma":[0.006867416,0.0003302824,0.0006130969,0.0006312748,0.00194451,0.003006129,0.0005937693,0.005118127,0.0009819635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139146,"about_ca_system_score_gemma":0.0008704355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006937803,"about_ca_topic_score_gemma":0.001593396,"domain_scores_codex":[0.9975642,0.0007106904,0.0002442754,0.0003236348,0.0009660644,0.0001911927],"domain_scores_gemma":[0.9968296,0.001617067,0.0003782457,0.0001416494,0.0008779351,0.0001555441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003913342,0.0000812483,0.003712651,0.00323722,0.0003785791,0.002457745,0.0006242384,0.0003462162,0.02916433,0.0397251,0.3786436,0.5412377],"study_design_scores_gemma":[0.00004425517,0.0001305925,0.001226915,0.0004258457,0.0001487583,0.003932754,0.0002469123,0.0001586461,0.006431418,0.0110404,0.9761861,0.00002745289],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.007364411,0.7371501,0.006542631,0.2058608,0.03620449,0.00003686254,0.00009308874,0.0001399491,0.006607654],"genre_scores_gemma":[0.05876845,0.5842679,0.005865543,0.27862,0.05702716,0.0001193248,0.0001940649,0.0001341088,0.01500355],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004518302,"threshold_uncertainty_score":0.02389532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1166534383568379,"score_gpt":0.3825374220982916,"score_spread":0.2658839837414537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}