{"id":"W4317107798","doi":"10.1158/1538-7445.metastasis22-a024","title":"Abstract A024: A potent eIF4A1/2 inhibitor CR-1-31B down-modulates the antioxidant stress response in osteosarcoma cells and inhibits <i>in vivo</i> lung metastases","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"In vivo; Cancer research; Oxidative stress; Metastasis; Integrated stress response; Ex vivo; Pharmacology; Chemistry; Medicine; Biology; Cancer; Messenger RNA; Biochemistry; Translation (biology); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189205,0.0005084337,0.0004181638,0.0003261931,0.00020047,0.0003180526,0.0003054616,0.0002455368,0.004264209],"category_scores_gemma":[0.00009636017,0.0001433147,0.0003274966,0.0002525127,0.0001342212,0.0001428086,0.0001199008,0.000712571,0.0009793059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002451922,"about_ca_system_score_gemma":0.0004131495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009512781,"about_ca_topic_score_gemma":0.001584315,"domain_scores_codex":[0.9999269,0.00000805803,0.00001057713,0.00001535808,0.00002048994,0.00001857708],"domain_scores_gemma":[0.9999501,0.000007347865,0.00001145994,0.000005868697,0.000008557736,0.00001664982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001114079,0.0003050499,0.0002057081,0.0001537578,0.00002324109,0.0000629041,0.000006123039,0.0001350766,0.9919969,0.00007322049,0.0008337429,0.005090074],"study_design_scores_gemma":[0.0003984512,0.002586856,0.003982169,0.00001782046,0.00005732591,0.0003490164,0.00001739262,0.0009037618,0.9848762,0.00004850224,0.006753183,0.000009277583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791963,0.007863069,0.002133912,0.0004510134,0.0001868756,0.0001552352,0.003998489,0.0005926747,0.00542244],"genre_scores_gemma":[0.9767383,0.00398432,0.0030122,0.0002298854,0.00004733893,0.0001350865,0.007379693,0.00006276661,0.008410351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004264209,"threshold_uncertainty_score":0.01426518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02477858483911474,"score_gpt":0.3339127999723112,"score_spread":0.3091342151331965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}