{"id":"W4317212031","doi":"10.2217/frd-2022-0015","title":"The Effects of Palovarotene in Patients with Fibrodysplasia Ossificans Progressiva: A Plain Language Summary","year":2023,"lang":"en","type":"article","venue":"Future Rare Diseases","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"Daiichi Sankyo Europe; UCB Pharma; Incyte; BioCryst; Mead Johnson Nutrition; International Fibrodysplasia Ossificans Progressiva Association; Ultragenyx Pharmaceutical; Ipsen; Regeneron Pharmaceuticals; Pfizer","keywords":"Fibrodysplasia ossificans progressiva; Clinical trial; Medicine; Heterotopic bone; Myositis ossificans; Physical therapy; Bone formation; Dentistry; Surgery; Heterotopic ossification; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003085102,0.0001047354,0.0001578267,0.0000992089,0.00009816997,0.00001346276,0.00008081952,0.00006795013,0.00002583019],"category_scores_gemma":[0.0001187189,0.00005712542,0.00005962728,0.000446191,0.00008901479,0.0000372953,0.00001619069,0.000131783,0.00001620403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002309602,"about_ca_system_score_gemma":0.00009284024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005207675,"about_ca_topic_score_gemma":0.000008857719,"domain_scores_codex":[0.9992088,0.00005759683,0.0001642449,0.000159375,0.0002271579,0.0001828453],"domain_scores_gemma":[0.999335,0.0001474532,0.00006464013,0.0002922246,0.00005323901,0.0001074373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006202261,0.0006201103,0.9601692,0.0008029721,0.0001876346,0.0003517505,0.001193978,0.000003079893,0.0002819157,0.0003019169,0.010207,0.02526019],"study_design_scores_gemma":[0.001945332,0.000205765,0.9930654,0.0004781424,0.00007113966,0.000001500036,0.0006426238,0.00001253,0.0001808258,0.00001312685,0.00331103,0.00007264669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962214,0.0009076697,0.000002151387,0.001179557,0.0001963054,0.001021206,0.0001095726,0.0001042291,0.0002578862],"genre_scores_gemma":[0.9980898,0.0000734028,0.00001926606,0.00007406747,0.0001333354,0.0001938327,0.0006226239,0.00001585344,0.0007778223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03289612,"threshold_uncertainty_score":0.2329507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002490181814365724,"score_gpt":0.2267368739953984,"score_spread":0.2242466921810327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}