{"id":"W4317213615","doi":"10.1007/s00018-023-04687-x","title":"Detection of antibodies against the huntingtin protein in human plasma","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec; University of Toronto; Centre hospitalier universitaire de Québec; Princess Margaret Cancer Centre; Université Laval; Polytechnique Montréal; Structural Genomics Consortium","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; NIHR BioResource; Agence Nationale de la Recherche; Wellcome Trust; Huntington Society of Canada; Huntington's Disease Society of America","keywords":"Huntingtin; Antibody; Huntington's disease; Huntingtin Protein; Immune system; Immunology; Biology; Disease; Blot; Molecular biology; Virology; Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914545,0.0004943308,0.0003066103,0.0008620358,0.0003023043,0.0003479604,0.000168981,0.0005567786,0.001319467],"category_scores_gemma":[0.0006999826,0.0002268837,0.0001768227,0.0005259129,0.000172852,0.0001925671,0.0002331216,0.0003871556,0.0004375225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007310243,"about_ca_system_score_gemma":0.00007848802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003590563,"about_ca_topic_score_gemma":0.0003310526,"domain_scores_codex":[0.9995449,0.0001146705,0.00004176764,0.0001264825,0.0001203991,0.00005171277],"domain_scores_gemma":[0.9996864,0.0001274318,0.00004968582,0.00002661068,0.00007219123,0.00003769066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005714985,0.0002372801,0.07436112,0.0001727096,0.0001054524,0.0006265566,0.0005241086,0.00007080008,0.9000369,0.00007530012,0.0003122741,0.02290593],"study_design_scores_gemma":[0.0001106243,0.003165515,0.7160243,0.00009813302,0.0002020603,0.009601139,0.0005417721,0.00166277,0.2624876,0.0003624392,0.005709688,0.00003404472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918578,0.001983922,0.003520276,0.00004518763,0.00004089337,0.00006390145,0.0003277473,0.00007751797,0.002082599],"genre_scores_gemma":[0.990099,0.001067494,0.006006106,0.0001261097,0.00005132398,0.0001183888,0.0007805047,0.00001143042,0.001739549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319467,"threshold_uncertainty_score":0.004414082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782022966240667,"score_gpt":0.2639243435691168,"score_spread":0.2361041139067102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}