{"id":"W4317243039","doi":"10.3390/ph16010094","title":"The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy","year":2023,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Topoisomerase; Cancer cell; DNA repair; DNA damage; Biology; DNA; Cell cycle; Cell biology; Cancer research; DNA replication; Cancer; Cell division; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007111796,0.0002466248,0.0005660157,0.00005341189,0.0001088693,0.00001575953,0.0003237267,0.0002200504,0.00001034229],"category_scores_gemma":[0.00005404405,0.0001694825,0.0003707355,0.0001873347,0.00008918274,0.00000165929,0.0001135707,0.0001516424,0.000002641048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004872234,"about_ca_system_score_gemma":0.0002402921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003075225,"about_ca_topic_score_gemma":0.00004016156,"domain_scores_codex":[0.9984874,0.0001265219,0.0005661337,0.0003865079,0.0001224252,0.0003109832],"domain_scores_gemma":[0.9990293,0.0001629117,0.0002507697,0.0004155756,0.00007579304,0.00006564901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004904124,0.00005652497,9.188479e-7,0.001351254,0.0001807423,2.115958e-7,0.00001831833,0.000001317953,0.01174206,0.0005419918,0.0002567125,0.9858009],"study_design_scores_gemma":[0.0003259551,0.0000809774,6.644024e-7,0.0005756197,0.0001398388,0.000001566389,0.000007816108,0.000008846295,0.03668997,0.0004074395,0.9615791,0.0001821648],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002959125,0.9969976,0.00006837038,0.0003134689,0.0004243465,0.001602421,0.0002504743,0.00001017078,0.00003721342],"genre_scores_gemma":[0.0007563198,0.9965081,0.00001876855,0.0001239567,0.0002994406,0.001835328,0.00008424972,0.00006148186,0.0003123967],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9856188,"threshold_uncertainty_score":0.6911294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1658117626730527,"score_gpt":0.480934091815984,"score_spread":0.3151223291429313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}