{"id":"W4317243039","doi":"10.3390/ph16010094","title":"The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy","year":2023,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Topoisomerase; Cancer cell; DNA repair; DNA damage; Biology; DNA; Cell cycle; Cell biology; Cancer research; DNA replication; Cancer; Cell division; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003807723,0.0006507352,0.0008214004,0.001365427,0.0002077121,0.0007294624,0.0006772504,0.0008032416,0.004343846],"category_scores_gemma":[0.0003793431,0.0002258847,0.000491071,0.001123115,0.0003211431,0.0008763419,0.0004175919,0.002042308,0.002402042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006034758,"about_ca_system_score_gemma":0.000522188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005395102,"about_ca_topic_score_gemma":0.001353264,"domain_scores_codex":[0.9998695,0.00002203399,0.00001341348,0.00002157876,0.00005805505,0.00001542675],"domain_scores_gemma":[0.9998548,0.00007093575,0.00001895205,0.0000050221,0.00003511785,0.00001505836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001133092,0.0001202576,0.000095077,0.01323977,0.0001063168,0.0002825231,0.00005307424,0.0006323879,0.005858335,0.007424592,0.04294514,0.9291292],"study_design_scores_gemma":[0.00002532534,0.0001318642,0.0003706442,0.001151767,0.00006959671,0.0008100201,0.00002032039,0.0001086936,0.001049898,0.001802766,0.9944468,0.00001232944],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002988069,0.9964694,0.0002377215,0.0003163343,0.0002761752,0.000008088209,0.00003566185,0.00001667947,0.002341264],"genre_scores_gemma":[0.001193851,0.9968175,0.0002385002,0.0002639435,0.0001325952,0.00001043301,0.00004226977,0.000002735957,0.001298223],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004343846,"threshold_uncertainty_score":0.01453161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1658117626730527,"score_gpt":0.480934091815984,"score_spread":0.3151223291429313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}