{"id":"W4317254563","doi":"10.1158/1078-0432.ccr-22-2263","title":"A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Medical Research Council; Cancer Research UK","keywords":"Cancer; Monocarboxylate transporter; Medicine; Transporter; Pharmacology; Internal medicine; Oncology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001177501,0.0001642786,0.0003784634,0.0001643272,0.00006636333,0.00001596832,0.0002537529,0.0001761655,0.00004349142],"category_scores_gemma":[0.00007763269,0.0001384468,0.00007634323,0.0007331754,0.0001963799,0.00002023995,0.00007844472,0.0003987232,0.000003400266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003967865,"about_ca_system_score_gemma":0.0003970963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009498231,"about_ca_topic_score_gemma":0.007677848,"domain_scores_codex":[0.9973185,0.0003615984,0.000596011,0.0006683216,0.0005749493,0.0004806077],"domain_scores_gemma":[0.9987696,0.00004279955,0.0001078955,0.0004812158,0.0004033477,0.0001951246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01331014,0.006463562,0.6098493,0.00006203409,0.0001551669,0.000005895131,0.0007929525,0.0009109106,0.01840409,0.000002707598,0.0009580501,0.3490852],"study_design_scores_gemma":[0.02731395,0.009851131,0.947508,0.00008196136,0.00004072798,7.688671e-8,0.0003754206,0.0001700237,0.003134906,0.00002328423,0.01122196,0.0002785751],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973455,0.0007473799,0.000005664054,0.00007190592,0.0006570663,0.00103516,0.00008474143,0.00001601935,0.00003653693],"genre_scores_gemma":[0.9963995,0.002110168,0.00002499173,0.00004791947,0.000697571,0.0004018613,0.0001163923,0.00004100444,0.0001606318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3488066,"threshold_uncertainty_score":0.5645698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184090983225074,"score_gpt":0.4943255930660395,"score_spread":0.3759164947435321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}