{"id":"W4317254563","doi":"10.1158/1078-0432.ccr-22-2263","title":"A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Medical Research Council; Cancer Research UK","keywords":"Cancer; Monocarboxylate transporter; Medicine; Transporter; Pharmacology; Internal medicine; Oncology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001285714,0.001421254,0.001464867,0.0004650508,0.0003855582,0.0006969157,0.0006549484,0.000837696,0.002120943],"category_scores_gemma":[0.0008277963,0.0004858715,0.0009083049,0.0005040409,0.0006991449,0.000629698,0.0003161462,0.002561253,0.0005782978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009175027,"about_ca_system_score_gemma":0.001122206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006539184,"about_ca_topic_score_gemma":0.001654448,"domain_scores_codex":[0.9995688,0.0001768831,0.00002696143,0.00008594742,0.00004880804,0.00009262739],"domain_scores_gemma":[0.9993906,0.00008375262,0.0001469943,0.00006900244,0.00003902027,0.0002704896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5596911,0.106209,0.01854752,0.0009853845,0.001533475,0.0004689261,0.0007535837,0.006900414,0.1325357,0.0003517441,0.004282114,0.1677412],"study_design_scores_gemma":[0.4173211,0.5457877,0.0227751,0.00003281702,0.0003776882,0.0004702043,0.0000564738,0.001772688,0.007597073,0.0002311315,0.003540737,0.00003732398],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955313,0.001150067,0.0003828147,0.000228527,0.00005026999,0.001300917,0.0004440138,0.00005402974,0.0008580684],"genre_scores_gemma":[0.9950057,0.0007102941,0.001150739,0.0003939172,0.00006106676,0.0009051216,0.0008679217,0.00001438934,0.0008909229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120943,"threshold_uncertainty_score":0.007095277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184090983225074,"score_gpt":0.4943255930660395,"score_spread":0.3759164947435321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}