{"id":"W4317350983","doi":"10.1182/blood.2022017174","title":"Aging alters the cell cycle control and mitogenic signaling responses of human hematopoietic stem cells","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Stem cell; Biology; Cell biology; Haematopoiesis; Population; Growth factor; Bone marrow; Immunology; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058591,0.0001739636,0.0001213701,0.0003256667,0.0000814713,0.0001623711,0.00006082795,0.0001064199,0.0009982245],"category_scores_gemma":[0.0001323247,0.00006620715,0.0001096433,0.0001419371,0.00007711896,0.000109953,0.0001040039,0.0001402437,0.0001773201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009550877,"about_ca_system_score_gemma":0.0001109286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003701296,"about_ca_topic_score_gemma":0.0004264269,"domain_scores_codex":[0.9999464,0.000008949514,0.000006212606,0.0000148589,0.00001117115,0.00001239792],"domain_scores_gemma":[0.9999536,0.000008841215,0.00001311753,0.000006055756,0.000007473262,0.0000108598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002846428,0.00004953601,0.005356449,0.00003658266,0.000008292385,0.00007164197,0.00005339529,0.00008391387,0.9869459,0.00009322479,0.00005935812,0.006957092],"study_design_scores_gemma":[0.00003090056,0.001834403,0.3225091,0.00001768592,0.00005668711,0.001291292,0.0001276327,0.001055866,0.6674268,0.0002382147,0.005398239,0.00001317207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956862,0.002666536,0.000593101,0.00002761839,0.000009289841,0.00001447534,0.0002627226,0.00001929947,0.0007208245],"genre_scores_gemma":[0.997372,0.001119501,0.0004393794,0.00003726796,0.00001003086,0.00001763111,0.0003768607,0.000004069803,0.0006232635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009982245,"threshold_uncertainty_score":0.00333941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812628598788042,"score_gpt":0.2607044546689858,"score_spread":0.2425781686811054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}