{"id":"W4317358041","doi":"10.1016/j.imbio.2023.152340","title":"Deregulated phenotype of autoreactive Th17 and Treg clone cells in pemphigus vulgaris after in-vitro treatment with desmoglein antigen (Dsg-3)","year":2023,"lang":"en","type":"article","venue":"Immunobiology","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Deanship of Scientific Research, King Saud University; Science and Engineering Research Board; King Abdulaziz University; Department of Science and Technology, Ministry of Science and Technology, India; Mount Royal University","keywords":"FOXP3; Pemphigus vulgaris; RAR-related orphan receptor gamma; CD80; Immunology; IL-2 receptor; CD86; Biology; T cell; Immune system; CD40; Cytotoxic T cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197501,0.0002562361,0.0006968484,0.0003712059,0.0000276785,0.000004948335,0.00008098437,0.0001929255,0.00008214432],"category_scores_gemma":[0.0000295134,0.000193286,0.00006363621,0.0004564593,0.000307134,0.00004329106,0.00006961085,0.0001379973,0.00003679497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818446,"about_ca_system_score_gemma":0.0001929666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002541087,"about_ca_topic_score_gemma":0.000209646,"domain_scores_codex":[0.9986116,0.0001304502,0.000374819,0.0003776512,0.000084393,0.0004210474],"domain_scores_gemma":[0.9992147,0.0001613007,0.0001292037,0.0003861315,0.00005437967,0.00005428101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01183917,0.0009628005,0.2882289,0.00007434919,0.0004570235,0.0009893349,0.003046689,0.00002296227,0.6812032,0.00001159879,0.00004260912,0.01312131],"study_design_scores_gemma":[0.004637674,0.001280524,0.9166492,0.0001294921,0.00009864534,0.00004989179,0.0003566604,0.0001029283,0.07612282,0.00005700164,0.0003371798,0.0001780392],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947782,0.004026348,0.000003607163,0.0001868802,0.00007380465,0.0006141091,0.00003809841,0.00007145249,0.000207494],"genre_scores_gemma":[0.9985363,0.0006000584,0.0001449031,0.00004913313,0.00001379863,0.0001010927,0.0001556658,0.00003788582,0.0003611703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6284202,"threshold_uncertainty_score":0.7881973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00794130444913577,"score_gpt":0.2403751259698914,"score_spread":0.2324338215207556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}