{"id":"W4317373145","doi":"10.1101/2023.01.17.524225","title":"A chemical probe to modulate human GID4 Pro/N-degron interactions","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Western University; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Genentech; Mitacs; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Argonne National Laboratory; U.S. Department of Energy; McGill University; Bayer; Pfizer; Deutsche Forschungsgemeinschaft; Bristol-Myers Squibb","keywords":"Degron; Ubiquitin; Cell biology; Helicase; Protein degradation; Ubiquitin ligase; Biology; Biochemistry; Protein–protein interaction; RNA-binding protein; RNA; Plasma protein binding; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657656,0.0003435637,0.0001415573,0.0001456977,0.0001242844,0.0001662531,0.0002270282,0.000383256,0.001368635],"category_scores_gemma":[0.0001231439,0.00009558111,0.0002050425,0.00009550585,0.0001857955,0.0001180916,0.0001538607,0.0004195141,0.0003293969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004318005,"about_ca_system_score_gemma":0.0001457855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003720148,"about_ca_topic_score_gemma":0.0004821366,"domain_scores_codex":[0.9998655,0.00002107294,0.000005642355,0.00003519101,0.00003394889,0.00003862032],"domain_scores_gemma":[0.9999352,0.00002133326,0.00001598753,0.000005577152,0.000008331547,0.00001367765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006259032,0.00001390162,0.00005698887,0.00002033689,0.000003481619,0.00001357211,0.000003491334,0.00004196657,0.9992174,0.00004993778,0.00002946888,0.0004870091],"study_design_scores_gemma":[0.00000509511,0.0001688028,0.0002811266,0.000001096009,0.000004552975,0.00005721797,0.000005060288,0.0003006387,0.9981534,0.00001131051,0.001010166,0.000001540949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986679,0.003035858,0.00708492,0.0001814562,0.00005472596,0.00005717521,0.0002896688,0.0001045288,0.002512584],"genre_scores_gemma":[0.9911081,0.0008787544,0.004909314,0.000129457,0.00001054902,0.00003906359,0.0004044958,0.00001880393,0.00250163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368635,"threshold_uncertainty_score":0.00457859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919960510486317,"score_gpt":0.2645367134429059,"score_spread":0.2353371083380427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}