{"id":"W4317380799","doi":"10.1016/j.nbd.2023.106005","title":"Neuro-immune crosstalk in depressive symptoms of multiple sclerosis","year":2023,"lang":"en","type":"review","venue":"Neurobiology of Disease","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Multiple sclerosis; Antidepressant; Immune system; Depression (economics); Context (archaeology); Psychiatry; Psychology; Medicine; Major depressive disorder; Depressive symptoms; Crosstalk; Neuroscience; Clinical psychology; Cognition; Immunology; Anxiety; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009492401,0.0004757519,0.001712915,0.0005019471,0.00005747106,0.00001291524,0.0009797057,0.0002625802,0.00004219692],"category_scores_gemma":[0.003042326,0.0004167094,0.0007317868,0.0009185421,0.0008599578,0.00007553366,0.0004310446,0.0004266783,0.00007064791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001912291,"about_ca_system_score_gemma":0.0002547914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002218891,"about_ca_topic_score_gemma":0.000008575115,"domain_scores_codex":[0.9965829,0.0007424473,0.001074661,0.0009413584,0.0001717257,0.000486894],"domain_scores_gemma":[0.9958813,0.002342411,0.0007970271,0.0007850151,0.00003254976,0.0001617671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001210715,0.004549838,0.005177325,0.1002849,0.000311066,0.0003906674,0.0003013062,0.0003087223,0.04644407,0.001181136,0.001284478,0.8385558],"study_design_scores_gemma":[0.02724548,0.005196268,0.1805334,0.1198746,0.004259336,0.00005774324,0.0001113702,0.0002583351,0.05229214,0.002586482,0.5971763,0.01040854],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09516926,0.9001893,0.000001722725,0.00003849532,0.0008087754,0.001709294,0.001804293,0.0001623889,0.0001164967],"genre_scores_gemma":[0.05630565,0.9431252,0.000002935566,0.00013379,0.00002733636,0.0001446464,0.00006947244,0.00009702272,0.00009395502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8281472,"threshold_uncertainty_score":0.9998285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08445001255986236,"score_gpt":0.3103818872303588,"score_spread":0.2259318746704964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}