{"id":"W4317388006","doi":"10.1038/s12276-022-00923-9","title":"Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis","year":2023,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"VDAC1; Parkin; Ubiquitin; Biology; Cell biology; Mitochondrion; Molecular biology; Autophagy; Biochemistry; Apoptosis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009507805,0.0001475455,0.0001909383,0.000193189,0.00003752332,0.000005774987,0.0000744842,0.0001457706,0.0001105019],"category_scores_gemma":[0.0001394679,0.000146081,0.00004110834,0.0003307467,0.0001063197,0.000006106837,0.00007962416,0.0000685214,0.00002048011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001716452,"about_ca_system_score_gemma":0.00001963914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002585273,"about_ca_topic_score_gemma":0.000005430482,"domain_scores_codex":[0.9988603,0.000117813,0.0002899466,0.0003611771,0.0001908227,0.0001799519],"domain_scores_gemma":[0.999551,0.00001740562,0.00009336363,0.0002000255,0.00005250589,0.00008567374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322242,0.00004816302,0.0001309201,0.00001796858,0.000007497754,0.00003972332,0.000427246,0.00002570065,0.996669,0.0003320184,0.001714736,0.000354788],"study_design_scores_gemma":[0.001773123,0.0007308434,0.00175641,0.00004640663,0.000008008426,0.00001595803,0.0002883255,0.00009820091,0.9874542,0.00001228418,0.007686613,0.000129574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942299,0.003409184,0.0005813685,0.000185388,0.0004810061,0.0003008791,0.00001086567,0.00002023611,0.0007812069],"genre_scores_gemma":[0.9973642,0.0008450809,0.000313351,0.0002055153,0.0003029048,0.0000390038,0.0005707671,0.00002363369,0.0003355706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009214762,"threshold_uncertainty_score":0.5957012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536857592429793,"score_gpt":0.269616480144424,"score_spread":0.2542479042201261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}