{"id":"W4317388006","doi":"10.1038/s12276-022-00923-9","title":"Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis","year":2023,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"VDAC1; Parkin; Ubiquitin; Biology; Cell biology; Mitochondrion; Molecular biology; Autophagy; Biochemistry; Apoptosis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717968,0.0001876447,0.0002188422,0.0001564361,0.0001799786,0.0002263601,0.0001147833,0.0002594017,0.001048686],"category_scores_gemma":[0.0001065359,0.0001322644,0.0001657338,0.00009555896,0.0002398771,0.0002101077,0.0001742653,0.0002901855,0.0001785767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989115,"about_ca_system_score_gemma":0.0001103861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001983479,"about_ca_topic_score_gemma":0.000272628,"domain_scores_codex":[0.9998831,0.00002682636,0.00001392867,0.00003099277,0.00001733798,0.00002785993],"domain_scores_gemma":[0.9998846,0.00001331381,0.00004719175,0.00001424984,0.00001186765,0.00002873621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001065463,0.00001680277,0.0003707191,0.00002384612,0.000003005572,0.00002979123,0.000009107715,0.00003327717,0.9988882,0.00005916342,0.00001187736,0.0004475734],"study_design_scores_gemma":[0.00002066812,0.00029075,0.01117789,0.000007141703,0.00001573426,0.0006681085,0.00004339715,0.001040787,0.9853161,0.00009528458,0.001319046,0.000005057541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960616,0.001562983,0.001912609,0.00004918064,0.00001144556,0.000008340819,0.00005296524,0.00002492187,0.0003159411],"genre_scores_gemma":[0.9985726,0.000310997,0.0005020345,0.00001690438,0.000002372855,0.000005854278,0.00005159403,0.000002998285,0.0005345906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048686,"threshold_uncertainty_score":0.00350821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536857592429793,"score_gpt":0.269616480144424,"score_spread":0.2542479042201261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}