{"id":"W4317394375","doi":"10.3390/cancers15030571","title":"Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McMaster University; Ottawa Hospital","funders":"Canadian Cancer Society","keywords":"Doxycycline; Medicine; Matrix metalloproteinase; Internal medicine; Oncology; MMP2; MMP9; Breast cancer; Cancer; Gastroenterology; Downregulation and upregulation; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322464,0.0001588342,0.0004575653,0.0001408699,0.0001184178,0.0002281873,0.0001045648,0.0002148752,0.001297951],"category_scores_gemma":[0.0005478107,0.00009571792,0.0002148365,0.0002030286,0.0001023625,0.0001413236,0.0001233705,0.0004511812,0.0001642086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633265,"about_ca_system_score_gemma":0.0001786174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003804909,"about_ca_topic_score_gemma":0.0009470676,"domain_scores_codex":[0.9998623,0.0000277702,0.00001724587,0.00003571148,0.00002716343,0.00002967398],"domain_scores_gemma":[0.9996001,0.00008637544,0.0001445077,0.00003164287,0.00003145236,0.0001058952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03511526,0.001240589,0.8483025,0.0002239536,0.0003381784,0.001187323,0.0001678564,0.0004254195,0.07203744,0.00007275162,0.00048271,0.04040609],"study_design_scores_gemma":[0.0003337123,0.009918712,0.9845858,0.000009217559,0.0001322645,0.001104456,0.00005124181,0.0003744281,0.002525497,0.00004826175,0.0009097491,0.000006607734],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986639,0.0005470272,0.00009331439,0.00002167152,0.000004687546,0.0000169231,0.0002020169,0.000004292351,0.0004462452],"genre_scores_gemma":[0.9990224,0.0001107738,0.00006360141,0.00002375498,0.000008017526,0.00001697577,0.0002832611,0.000001215973,0.000470081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297951,"threshold_uncertainty_score":0.004342079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488150786245183,"score_gpt":0.2623265963638302,"score_spread":0.2374450885013784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}