{"id":"W4317395163","doi":"10.3389/fonc.2023.1073491","title":"Theranostic 64Cu-DOTHA2-PSMA allows low toxicity radioligand therapy in mice prostate cancer model","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Université de Sherbrooke; Merck Canada; Cancer Research Society","keywords":"Medicine; Prostate cancer; Toxicity; LNCaP; Radionuclide therapy; Radioligand; Nuclear medicine; Dosimetry; In vivo; Prostate; Therapeutic index; Radiation therapy; Cancer; Cancer research; Internal medicine; Pharmacology; Drug; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625461,0.0001618575,0.0004342827,0.0001331026,0.00004414771,0.000006546648,0.0001536555,0.0002094921,0.00005092856],"category_scores_gemma":[0.00006061899,0.0001467959,0.0000604146,0.0005690704,0.0001640022,0.00004578836,0.00002429469,0.0004211566,0.00001637273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402636,"about_ca_system_score_gemma":0.0003237586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004237313,"about_ca_topic_score_gemma":0.0000309414,"domain_scores_codex":[0.9987237,0.00005794137,0.0003130997,0.0003551273,0.0001230919,0.0004270278],"domain_scores_gemma":[0.9994683,0.0001099593,0.00005625318,0.0001941556,0.00003135951,0.0001400107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003073416,0.001350591,0.1248841,0.0002550785,0.0001774621,0.0004458306,0.004093395,0.0238859,0.6796888,0.0001129729,0.06731368,0.09471881],"study_design_scores_gemma":[0.02144499,0.0006195807,0.02903935,0.0002861634,0.0001092616,0.00007453514,0.0009622998,0.6050556,0.2409615,0.006043612,0.09455425,0.0008488211],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98812,0.00140767,0.0006484057,0.00643524,0.0002989604,0.0007662484,0.00003028885,0.0000792155,0.002213985],"genre_scores_gemma":[0.9870245,0.006524703,0.001575221,0.0019868,0.0001536155,0.0005294472,0.0000377299,0.00002903115,0.002138899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5811697,"threshold_uncertainty_score":0.5986163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208057638588906,"score_gpt":0.3590707246318482,"score_spread":0.3269901482459591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}