{"id":"W4317425523","doi":"10.3390/ijms24031971","title":"Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université du Québec à Montréal","funders":"National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois","keywords":"Neuroprotection; Endoplasmic reticulum; Unfolded protein response; Autophagy; Sigma-1 receptor; Cell biology; Subcellular localization; Mitochondrion; Flux (metallurgy); Biology; Chemistry; Neuroscience; Biochemistry; Cytoplasm; Apoptosis; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008469976,0.0001692687,0.0004631803,0.000293567,0.00003189724,0.00003785231,0.0005107459,0.0001749261,0.00002403741],"category_scores_gemma":[0.00018833,0.0001191406,0.0002947638,0.0002943728,0.0001601215,0.000009314068,0.0001874608,0.0002222939,0.000004435476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000246162,"about_ca_system_score_gemma":0.000123417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000585422,"about_ca_topic_score_gemma":0.000001598708,"domain_scores_codex":[0.9984247,0.0002445234,0.0005404977,0.0002762883,0.0003684052,0.000145561],"domain_scores_gemma":[0.999163,0.00006152947,0.0004981688,0.00007813302,0.0001336179,0.00006560518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006558261,0.0001728984,0.00003537362,0.000445698,0.0002536884,0.0001959274,0.00001459365,0.0001785275,0.252158,0.0006038711,0.000117234,0.7457587],"study_design_scores_gemma":[0.000700285,0.002300015,0.00009476398,0.00356566,0.0001380362,0.0006483085,0.00008928998,0.00006289935,0.02133638,0.001489182,0.969111,0.0004641473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03336278,0.9647939,0.0007414716,0.00003172304,0.0007914032,0.0001769948,0.00001403424,0.000003501217,0.00008417344],"genre_scores_gemma":[0.01834737,0.9812129,0.0001769653,0.00002944694,0.000180133,0.000009544779,0.0000121048,0.0000109253,0.00002066352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9689938,"threshold_uncertainty_score":0.4858411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048286771414206,"score_gpt":0.3749610683930759,"score_spread":0.2701323912516552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}