{"id":"W4317425760","doi":"10.3390/genes14020254","title":"Towards a Cure for HARS Disease","year":2023,"lang":"en","type":"review","venue":"Genes","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Aminoacyl tRNA synthetase; Histidine; Biology; Transfer RNA; Amino acid; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003965716,0.000666838,0.0008678905,0.00131612,0.0002204878,0.0008043254,0.0006558835,0.001395815,0.00381674],"category_scores_gemma":[0.0004390226,0.000170043,0.0003536867,0.0006675915,0.0004497307,0.001235216,0.0006527394,0.00265652,0.00352575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003930975,"about_ca_system_score_gemma":0.0003921801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003181099,"about_ca_topic_score_gemma":0.0005984129,"domain_scores_codex":[0.9998797,0.00002046694,0.00001311015,0.00002318129,0.0000478271,0.00001566264],"domain_scores_gemma":[0.9998646,0.00006538437,0.00001531249,0.000005354397,0.00003031622,0.00001917417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001026373,0.00009348486,0.00009783638,0.008050884,0.00005913124,0.0004028554,0.00005273042,0.0002454547,0.004721368,0.009459229,0.0567802,0.9199342],"study_design_scores_gemma":[0.00001719312,0.00005746377,0.0001788837,0.001155679,0.00003148286,0.001304547,0.00002375085,0.00004733485,0.0005566507,0.002335796,0.9942836,0.000007667295],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001851466,0.9965459,0.000299572,0.000820449,0.0005481121,0.000004044548,0.0000192481,0.0000228844,0.001554671],"genre_scores_gemma":[0.00123316,0.9941096,0.000530544,0.001075201,0.0004461165,0.00001123913,0.00005998882,0.000009144057,0.002525024],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00381674,"threshold_uncertainty_score":0.01276833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07829536728964091,"score_gpt":0.3540387859987393,"score_spread":0.2757434187090984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}