{"id":"W4317425760","doi":"10.3390/genes14020254","title":"Towards a Cure for HARS Disease","year":2023,"lang":"en","type":"review","venue":"Genes","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Aminoacyl tRNA synthetase; Histidine; Biology; Transfer RNA; Amino acid; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587069,0.0002827376,0.0005211515,0.00004755442,0.00006926443,0.0000300717,0.0003151108,0.0002892102,0.00002043715],"category_scores_gemma":[0.00009414327,0.0002275033,0.0006178034,0.00007174382,0.00002124951,8.673551e-7,0.0001179246,0.0000418753,0.00008916979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008221177,"about_ca_system_score_gemma":0.0002994958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002579271,"about_ca_topic_score_gemma":0.00000287791,"domain_scores_codex":[0.9989129,0.00006086019,0.0002358388,0.0004502717,0.00009404268,0.0002461151],"domain_scores_gemma":[0.999247,0.00001673269,0.0001192249,0.0004572404,0.00003758592,0.0001222337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001147606,0.00001002326,1.617602e-7,0.007068486,0.0001388817,0.000004191216,0.000001635083,3.905044e-7,0.0003334366,0.0001116971,0.005112406,0.9872072],"study_design_scores_gemma":[0.00006025861,0.00005078844,2.478494e-7,0.001082521,0.000335962,0.000003153543,0.000002252932,7.413545e-7,0.0009977499,0.0003412641,0.9968416,0.0002834658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003196586,0.9965242,0.00146246,0.00003953509,0.0004216284,0.0009096268,0.0005397311,0.00002997234,0.00006972205],"genre_scores_gemma":[7.507288e-7,0.9905593,0.0008037871,0.0000455671,0.0009416461,0.001197257,0.0009365928,0.0001004313,0.005414696],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9917292,"threshold_uncertainty_score":0.9277315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07829536728964091,"score_gpt":0.3540387859987393,"score_spread":0.2757434187090984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}