{"id":"W4317433563","doi":"10.2217/fon-2022-0919","title":"A real-world study of second or later-line osimertinib in patients with EGFR T790M-positive NSCLC: the final ASTRIS data","year":2023,"lang":"en","type":"article","venue":"Future Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; William Osler Health System; BC Cancer Agency; University of Toronto","funders":"AstraZeneca","keywords":"Osimertinib; Medicine; T790M; Oncology; Internal medicine; Second line; Real world data; First line; Epidermal growth factor receptor; Gefitinib; Cancer; Erlotinib; Data science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006579688,0.0009292588,0.001687142,0.0004692721,0.0004185434,0.001726539,0.0006990207,0.0007933986,0.002140554],"category_scores_gemma":[0.003501859,0.0003935229,0.002710387,0.0008398027,0.0005836013,0.0008043449,0.0006884043,0.001010168,0.000800164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001221084,"about_ca_system_score_gemma":0.001205006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128169,"about_ca_topic_score_gemma":0.003071581,"domain_scores_codex":[0.9963785,0.001971037,0.0004004719,0.0004135044,0.0006513174,0.0001850564],"domain_scores_gemma":[0.9953327,0.001130844,0.001866776,0.0006442762,0.0005636657,0.0004617419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2529048,0.004568575,0.6180722,0.003529517,0.02588231,0.0008875644,0.0005323688,0.005592855,0.01447447,0.0006381728,0.01231712,0.06059999],"study_design_scores_gemma":[0.04379084,0.05366692,0.8352541,0.0003449024,0.01623284,0.002600407,0.0004373709,0.003435537,0.009601639,0.000418295,0.03398653,0.0002305489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794202,0.004774924,0.0006612205,0.0004460719,0.0000516063,0.0005734033,0.01112557,0.00003721297,0.002909839],"genre_scores_gemma":[0.9615915,0.001220833,0.001181201,0.0004793265,0.0001288944,0.0005324159,0.03382295,0.00003146297,0.00101137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006579688,"threshold_uncertainty_score":0.03479707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0400914084856207,"score_gpt":0.3892553444016239,"score_spread":0.3491639359160032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}