{"id":"W4317436165","doi":"10.1016/j.molcel.2022.12.028","title":"SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease","year":2023,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institutes of Health; Genome Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Glioma; Biology; Epigenetics; Cancer research; Physics; Internal medicine; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346229,0.0002971298,0.0002165478,0.0003672417,0.000282459,0.0003738516,0.0002595581,0.0005100298,0.002703568],"category_scores_gemma":[0.0002062855,0.0001323631,0.0001680716,0.0001907408,0.0004315379,0.0002733829,0.0003850014,0.0006499868,0.0004839833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003598553,"about_ca_system_score_gemma":0.0002965265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005759452,"about_ca_topic_score_gemma":0.0008303291,"domain_scores_codex":[0.9999219,0.000009258189,0.000005128534,0.00001670097,0.00002641758,0.00002051404],"domain_scores_gemma":[0.9998804,0.00001261548,0.00002878826,0.00002142539,0.00001181682,0.00004483095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005219803,0.00002364615,0.005856655,0.00004916639,0.00004183407,0.003678097,0.00006061531,0.0002152228,0.976067,0.00346169,0.001272833,0.008751221],"study_design_scores_gemma":[0.0001323407,0.001151382,0.08667789,0.00007219503,0.0002028034,0.05431642,0.0006958185,0.003135763,0.8033389,0.0126192,0.03759308,0.00006411217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859227,0.00171471,0.003140513,0.002694228,0.00009894188,0.00001631312,0.0005415468,0.0004631402,0.005407941],"genre_scores_gemma":[0.9964019,0.0005192008,0.0007026974,0.0001590003,0.00001839935,0.000007658712,0.000132824,0.00004517402,0.002013239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703568,"threshold_uncertainty_score":0.009044349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203714657304487,"score_gpt":0.2707621094172579,"score_spread":0.258724962844213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}