{"id":"W4317436165","doi":"10.1016/j.molcel.2022.12.028","title":"SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease","year":2023,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institutes of Health; Genome Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Glioma; Biology; Epigenetics; Cancer research; Physics; Internal medicine; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898037,0.000175277,0.0001576987,0.00006774336,0.00005154148,0.00001879589,0.0001760813,0.0001188299,0.00002502276],"category_scores_gemma":[0.0001367493,0.0001795175,0.0001890716,0.0002094587,0.00004949599,0.000001804533,0.000106773,0.00008750201,0.00002687799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002684535,"about_ca_system_score_gemma":0.0001114709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543829,"about_ca_topic_score_gemma":0.00001626855,"domain_scores_codex":[0.9987003,0.0000663127,0.0002282972,0.0005066749,0.0001456773,0.0003526904],"domain_scores_gemma":[0.9992794,0.00001847588,0.00004219059,0.0004667813,0.00006214799,0.0001309857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002447493,0.0001478404,0.0005753036,0.0001641817,0.00001672451,0.0001147924,0.00003659757,0.004941276,0.9884571,0.0000188796,0.004487182,0.0007954128],"study_design_scores_gemma":[0.004232972,0.0003157395,0.001708013,0.00004921481,0.00005995664,0.000009293676,0.00007008175,0.0223412,0.9135897,0.001461533,0.05541418,0.0007481017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937538,0.000969928,0.003764049,0.0004641686,0.0001233638,0.0003820519,0.00007592214,0.00003888781,0.0004278325],"genre_scores_gemma":[0.997431,0.00002796973,0.0006721313,0.0002828874,0.0001130657,0.0001675239,0.0004223792,0.00004040224,0.0008426845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07486735,"threshold_uncertainty_score":0.7320513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203714657304487,"score_gpt":0.2707621094172579,"score_spread":0.258724962844213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}