{"id":"W4317470309","doi":"10.1016/j.ctarc.2023.100683","title":"Real-world treatment outcomes in HR+ HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors: Results from a reference center in Brazil","year":2023,"lang":"en","type":"article","venue":"Cancer Treatment and Research Communications","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Discontinuation; Internal medicine; Tolerability; Palbociclib; Neutropenia; Adverse effect; Breast cancer; Metastatic breast cancer; Gastroenterology; Oncology; Febrile neutropenia; Population; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000988961,0.0002246994,0.000467251,0.0009923876,0.0002613415,0.0007101017,0.0003310639,0.0002843566,0.0008299628],"category_scores_gemma":[0.00375798,0.0001706107,0.0006025375,0.001532146,0.0003625505,0.0002932115,0.0005665378,0.0002627063,0.0001633505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001773379,"about_ca_system_score_gemma":0.001519601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03759288,"about_ca_topic_score_gemma":0.04077385,"domain_scores_codex":[0.9992342,0.0002210657,0.000121565,0.0001608905,0.0001479649,0.000114288],"domain_scores_gemma":[0.9971367,0.0005285558,0.001415574,0.0001795614,0.0004980151,0.0002414715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002467787,0.00006754175,0.9866899,0.0001545376,0.000136244,0.0002242672,0.0006227138,0.000217186,0.0003574557,0.0000982292,0.0005893336,0.0105959],"study_design_scores_gemma":[0.00007059094,0.0002263128,0.9956857,0.0001029624,0.0001199339,0.0005412155,0.0007461978,0.0003241336,0.0002139652,0.00004259735,0.001913358,0.00001299473],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941551,0.001498631,0.0002356096,0.0001902002,0.000006948343,0.00004751035,0.002609862,0.000009712898,0.001246433],"genre_scores_gemma":[0.9970885,0.000728593,0.0001488814,0.00007433214,0.000007927476,0.0000281525,0.001833107,0.000006835293,0.00008366159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03759288,"threshold_uncertainty_score":0.07474816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1223600503798934,"score_gpt":0.4448572747629137,"score_spread":0.3224972243830203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}