{"id":"W4317479778","doi":"10.1073/pnas.2210593120","title":"Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medisinske fakultet, Universitetet i Oslo; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norges Teknisk-Naturvitenskapelige Universitet; Centre National de la Recherche Scientifique; Helse Midt-Norge; Faculty of Medicine and Health, University of Sydney; Institut National de la Santé et de la Recherche Médicale; Université de Strasbourg; Eidgenössische Technische Hochschule Zürich; Universitetet i Oslo; Institute of Genetics; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Norges Forskningsråd; Agence Nationale de la Recherche; National Science Foundation","keywords":"Premature chromosome condensation; Interphase; Mitosis; Prophase; Chromatin; Cell biology; Biology; Transcription (linguistics); Transcription factor; Chromosome segregation; Histone; Cell cycle; Chromosome; Genetics; Gene; Meiosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233142,0.0001590412,0.0001659522,0.0002152012,0.000161713,0.0004591886,0.0002392218,0.0001783771,0.0008118597],"category_scores_gemma":[0.00023267,0.0001311242,0.0001186021,0.0001019222,0.0002889655,0.0002546447,0.0002977767,0.0003392892,0.0002743267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004005024,"about_ca_system_score_gemma":0.000216805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004753073,"about_ca_topic_score_gemma":0.00109256,"domain_scores_codex":[0.9999152,0.00000905998,0.000005577083,0.00001966506,0.00002565923,0.00002484712],"domain_scores_gemma":[0.9998579,0.00001833721,0.00004276491,0.00002410694,0.00001735316,0.00003939027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004358522,0.000004688678,0.0004422844,0.000009901953,0.000002086981,0.00003153041,0.00001083678,0.00004806534,0.9981869,0.0002134049,0.00001669258,0.0009899923],"study_design_scores_gemma":[0.00001671575,0.000177109,0.03669904,0.00000826565,0.00001004162,0.0002567271,0.0000597464,0.00145932,0.9587414,0.0002925512,0.002272618,0.000006497114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916494,0.001087151,0.004764512,0.0001181829,0.00002546045,0.00001691616,0.00009871446,0.0001035412,0.002136186],"genre_scores_gemma":[0.9976249,0.0002613788,0.0007807483,0.00004270596,0.00001216605,0.000007292596,0.0001132572,0.00002151872,0.001136048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008118597,"threshold_uncertainty_score":0.002905846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02596067967716703,"score_gpt":0.2913858608727752,"score_spread":0.2654251811956082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}