{"id":"W4317488765","doi":"10.1101/2023.01.19.524692","title":"Molecular and functional properties of human <i>Plasmodium falciparum</i> CSP C-terminus antibodies","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Argonne National Laboratory; Office of Science; National Cancer Institute; National Institutes of Health; Hospital for Sick Children; Deutsches Krebsforschungszentrum; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Epitope; Plasmodium falciparum; Circumsporozoite protein; Monoclonal antibody; Virology; Biology; Antibody; Linker; Conformational epitope; Epitope mapping; Molecular biology; Malaria vaccine; Genetics; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179451,0.0002695377,0.00007747772,0.0001084648,0.00007847485,0.0001644767,0.0001019666,0.0001610662,0.001497164],"category_scores_gemma":[0.0001496114,0.000061967,0.0001380663,0.0001252129,0.00009398319,0.00008080358,0.00005113042,0.0002005095,0.0004019938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162255,"about_ca_system_score_gemma":0.0001045354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001283543,"about_ca_topic_score_gemma":0.0006708755,"domain_scores_codex":[0.9999223,0.00001475828,0.000004411,0.00001751808,0.0000179642,0.00002299428],"domain_scores_gemma":[0.9999151,0.00002174582,0.00001201688,0.000006829353,0.00002253411,0.00002177047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280399,0.00002510893,0.0006767655,0.00002262263,0.000005735738,0.0000347287,0.0000111114,0.0001561697,0.9967116,0.00008473433,0.0001222774,0.002021133],"study_design_scores_gemma":[0.00002404362,0.000464504,0.01110269,0.000005413981,0.00002311553,0.0006207202,0.00001749786,0.001282751,0.983093,0.000061529,0.003300299,0.000004436692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927563,0.0009110178,0.002638235,0.00007879288,0.00001298938,0.00001828539,0.0005708811,0.0000400573,0.002973421],"genre_scores_gemma":[0.9955759,0.0003542342,0.001358906,0.00007231806,0.000009138081,0.00001224401,0.001272207,0.00001197709,0.001333178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497164,"threshold_uncertainty_score":0.005008459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291562540478705,"score_gpt":0.2506949827083798,"score_spread":0.2177793573035927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}